Acute and Chronic Post-COVID-19 Conditions: A Study of Genetic Integrity and Clinical Markers
Bruna Alves Alonso Martins, Ana Leticia Hilario Garcia, Malu Siqueira Borges, Daiane Dias Ribeiro Nobles, Alana Witt Hansen, Fernando Rosado Spilki, Lavínia Schuler-Faccini, Pabulo Henrique Rampelotto...
Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults
Nicholas Donnelly, Ruby Tsang, Èimear M Foley, Holly Fraser, Aimee Hanson, Golam M Khandaker
Background
Depression is associated with alterations in immuno-metabolic biomarkers, but it remains...
Full title: Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID
Abstract
Background
Patients with Long COVID (LC) often experience neuropsychiatric symptoms such as...
Pre-pandemic leukocyte count is associated with severity of post-acute sequelae of SARS-CoV-2 infection among older women in the Women's Health Initiative
Ted K S Ng, Hind A Beydoun, Diane Von Ah, Aladdin H Shadyab, Shu Cheng Wong, Matthew Freiberg, Farha Ikramuddin, Patricia K Nguyen, Philippe...
We've discussed CRP on a number of threads. There are some hints of mildly raised CRP in ME/CFS and some suggestion that levels may track with fluctuations of illness severity. But, there are a lot of confounding factors. I'm going to link some of the papers and discussions here.
When...
C-Reactive Protein (CRP) is Associated With Chronic Pain Independently of Biopsychosocial Factors
The Journal of Pain
Pre-print: https://pubmed.ncbi.nlm.nih.gov/37741522/
(Paragraphs added for legibility)
Inflammation is linked with chronic pain but the extent to which this relationship is...
Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study
https://www.nature.com/articles/s41398-023-02438-x
Abstract (paragraphs mine)
Compelling evidence demonstrates that some individuals suffering from major depressive disorder...
Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive tryptophan catabolites (TRYCATs), including kynurenine (KYN). The TRYCAT pathway has not been studied extensively in association...
Abstract
Many individuals who had COVID-19 develop detrimental persistent symptoms; a condition known as post-acute sequelae of COVID-19 (PASC). Despite the elevated risk of cardiovascular disease following COVID-19, limited studies have examined vascular function in PASC with equivocal results...
Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19
Hopkins FR, Govender M, Svanberg C, Nordgren J, Waller H, Nilsdotter-Augustinsson Å, Henningsson AJ, Hagbom M, Sjöwall J, Nyström S, Larsson M
Introduction: After more than two...
https://www.mdpi.com/2504-3900/80/1/6
Report from the Scientific Poster Session at the 16th Annual Cardiometabolic Health Congress in National Harbor, USA, 14–17 October 2021
[..]
2.12. The Role of Leptin and Inflammatory Related Biomarkers in Individuals with Myalgic...
Objective
The aim of the study is to investigate relationships between inflammatory analytes and symptoms of pain and fatigue in Gulf War illness (GWI).
Methods
In this preliminary study, 12 male veterans meeting GWI criteria provided daily blood samples and symptom ratings over 25 days...
This study aims to assess whether raised CRP (a blood test used as a marker of inflammation) is associated with probable depression in children and young people with CFS/ME.
CACH team: Sandy Royston, Maria Loades, Esther Crawley...
Full title:
Are Circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
https://www.liebertpub.com/doi/abs/10.1089/ars.2020.8230
I thought it would be good to start a thread for news and updates from Jarred Younger and his "Neuroinflammation, Pain, and Fatigue Laboratory" at UAB since he is active on Facebook and has a newsletter
Link to Facebook page...
Trying to understand where depression usefully features here. Given the repeated statements that somatic (but not cognitive nor affective) symptoms are associated with things like cardiac events and higher levels of CRP, IL-6 and TNF-alpha, it seems more reasonable to identify the specific...
Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/ chronic fatigue syndrome
AkikoEguchi,SanaeFukuda,HirohikoKuratsunede,JunzoNojimag,YasuhitoNakatomi,YasuyoshiWatanabee,Ariel E.Feldstein...
Full title: Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial
Open access, https://www.nature.com/articles/s41598-019-52260-z
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