Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ME/CFS patients often report...
Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights
August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad; Hans-Peter Marti; Olav Mella; Oystein...
Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study
Madlene Holmqvist; Dick J Sjöström; Katherine Carlson; Birgitta Gullstrand; Anders A Bengtsson; Robin Kahn; Tom E Mollnes; Per Åkesson; Per H Nilsson; Fredrik...
Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19
Jiangfeng Liu; Li Guo; Jingchuan Zhong; Yue Wu; Xinming Wang; Xiaoyue Tang; Kaiyuan Min; Yehong Yang; Wanjun Peng; Qiaochu Wang; Tao Ding; Xiaoying...
CspZ variant–specific interaction with factor H incorporates a metal site to support Lyme borreliae complement evasion
Kalvis Brangulis; Valerie Sürth; Ashley L. Marcinkiewicz; Inara Akopjana; Andris Kazaks; Janis Bogans; Alisa Huber; Yi-Pin Lin; Peter Kraiczy
Polymorphic microbial immune...
Background
Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with various symptoms such as fatigue and anxiety. Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and...
Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19
Yulin Wei, Hongyan Gu, Jun Ma, Xiaojuan Mao, Bing Wang, Weiyan Wu, Shimin Yu, Jinyuan Wang, Huan Zhao, yanbin he
[Preprint]
Abstract
Long COVID is an often-debilitating condition with...
Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions
Alejandro Seco-González, Paula Antelo-Riveiro, Susana B. Bravo, P.F. Garrido, M.J. Domínguez-Santalla, E. Rodríguez-Ruiz, Á. Piñeiro, R. Garcia-Fandino
Background
Persistent symptoms extending beyond...
2015 study
Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome
Mangalathu S. Rajeevan, Irina Dimulescu, Janna Murray 1, Virginia R. Falkenberg, Elizabeth R. Unger
Abstract
Recent evidence suggests immune and inflammatory alterations are...
Abstract:
The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been...
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping
Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities...
ABSTRACT
The complement system is a vital anti-microbial defence mechanism against circulating pathogens. Excessive complement activation can have deleterious outcomes for the host and is consequently tightly modulated by a set of membrane-associated and fluid-phase regulators of complement...
Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia
Yang Jiang; Jennifer Neal; Pradoldej Sompol; Görsev Yener; Xianghong Arakaki; Christopher M. Norris; Francesca R. Farina; Agustin Ibanez; Susanna Lopez; Abdulhakim Al-Ezzi; Voyko...
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