circadian

The Orexin System and Its Impact on the Autonomic Nervous and Cardiometabolic System in Post-Acute Sequelae of COVID-19 Jana Ruhrländer, Styliani Syntila, Elisabeth Schieffer, Bernhard Schieffe [Line break added] Abstract Orexins (OXs) are critical for regulating circadian rhythms, arousal...

Highlights: • Sleep complaints in PASC are frequent, varying from insomnia to excessive daytime sleepiness. • Five categories of sleep disorders syndromes were identified in PASC: obstructive sleep apnea, insomnia, primary hypersomnia, REM behavior disorder (RBD), and new onset circadian phase...

Sleep and circadian rhythm alterations in myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID fatigue syndrome and its association with cardiovascular risk factors: A prospective cohort study Abstract This study aimed to investigate circadian rhythm manifestations in Myalgic...

ME patients often have sleep disturbances not seen in the healthy population. This includes non-24, where the sleep hours advance each day, and circadian reversal, which is more recognized with African Sleeping Sickness. I have a history of this worsening, until my non-24 was advancing by many...

The Case for the Target of Rapamycin Pathway as a Candidate Circadian Oscillator Lakin-Thomas, Patricia The molecular mechanisms that drive circadian (24 h) rhythmicity have been investigated for many decades, but we still do not have a complete picture of eukaryotic circadian systems. Although...

Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping Siebieszuk, Adam; Sejbuk, Monika; Witkowska, Anna Maria The recently observed circadian oscillations of the intestinal microbiota underscore the profound nature of the...

Abstract Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies have so far largely failed to identify genetic...

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling disorder characterized by disrupted daily patterns of activity, sleep, and physiology. Past studies in ME/CFS patients have examined circadian rhythms, suggested that desynchronization between central and...

Thermosensitivity of translation underlies the mammalian nocturnal-diurnal switch Andrew David Beale; Nina M Rzechorzek; Andrei Mihut; Aiwei Zeng; Nicola J Smyllie; Violetta Pilorz; Rose Richardson; Mads F Bertlesen; Nathan R James; Shaline V Fazal; Zanna Voysey; Jerry Pelletier; Priya Crosby...

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact Willian A. da Silveira; Hossein Fazelinia; Sara Brin Rosenthal; Evagelia C. Laiakis; Man S. Kim; Cem Meydan; Yared Kidane; Komal S. Rathi; Scott M. Smith; Benjamin Stear; Yue Ying...

https://pubmed.ncbi.nlm.nih.gov/24060274/ Abstract Background: It remains elusive how allergic symptoms exhibit prominent 24-hour variations. In mammals the circadian clocks present in nearly all cells, including mast cells, drive the daily rhythms of physiology. Recently, we have shown that...

Post with a link to the final paper here ******** Source: Research Square Preprint Date: September 21, 2022 URL: https://www.researchsquare.com/article/rs-2044838/v1 Circadian skin temperature rhythm and dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the role...

https://www.bristol.ac.uk/phys-pharm-neuro/events/uk-clock-club/

Genetics of circadian rhythms and sleep in human health and disease Lane JM, Qian J, Mignot E, Redline S, Scheer FAJL, Saxena R Circadian rhythms and sleep are fundamental biological processes integral to human health. Their disruption is associated with detrimental physiological consequences...

Highlights • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by disrupted sleep and activity implicating circadian clocks. • The incidence of ME/CFS is expected to increase as a result of the post-acute sequelae of COVID-19. • Biomarker studies in ME/CFS patients...

High sensitivity and interindividual variability in the response of the human circadian system to evening light Andrew J. K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M. W. Rajaratnam, Steven W. Lockley, and Sean W. Cain Significance Electric...

I found this fascinating. I've always felt a rhythm to my illness and that my body was doing things at certain times of the day. I haven't done anything in the morning since 1991. https://www.quantamagazine.org/the-bodys-clock-offers-a-rhythmic-target-to-viruses-20190530/

A note for those who use sleep medication to help combat ME sleep issues - this might be more difficult to answer since the body becomes somewhat dependent on medication when taken chronically. If you could try to answer based on your time with ME before you ever took sleep meds or, if that is...

One of the most debilitating aspects of my ME is that the disease causes me major sleep inversion. On most evenings, after significant enough exertion builds up from the previous day(s), I primarily get a very strong brain wired-but-tired feeling and my gut starts becoming irritated. I also...

I saw this posted on the "ME/CFS-Evolving Science" facebook page... Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome Eiren Sweetman, Margaret Ryan, Christina Edgar, Angus MacKay, Rosamund Vallings, Warren...