cd8

Identifying Neuro-inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets based on machine learning approaches Jingjing Lu, Weiwei Liang, Lijun Cui, Shaoqi Mou, Xuedan Pei, Xinhua Shen, Zhongxia Shen, Ping Shen Introduction Activation of the inflammatory response system...

Now published: post with link here ******* Identification of soluble biomarkers that associate with distinct manifestations of long COVID Marcus Buggert, Yu Gao, Curtis Cai, Sarah Adamo, Elsa Biteus, Habiba Kamal, Lena Dager, Kelly Miners, Sian Llewellyn-Lacey, Kristin Ladell, Pragati...

Hypocortisolemic ASIA: A vaccine-and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis (Provisionally accepted) Manuel Ruiz-Pablos 1, Aintzane Zabaleta 2, Bruno Paiva 2 1 Complutense University of Madrid, Madrid, Madrid, Spain 2 Center of Applied...

Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID. Lucie Rodriguez; Ziyang Tan; Lakshmi Kanth Tadepally; Jun Wang; Hugo Barcenilla; Zoe Swank; Fanglei Zuo; Hassan Abolhassani; Ana Jimena Pavlovitch-Bedzyk; Chunlin Wang...

Abstract Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease, relatively little is known about the precise nature of the immune dysregulation underlying the development of the disease. Reasoning that the CSF from patients might be enriched for cells relevant in...

Persistent CD8+ T cell proliferation and activation in COVID-19 adult survivors with post-acute sequelae: a longitudinal, observational cohort study of persistent symptoms and T cell markers LaVergne, Stephanie M.; Dutt, Taru S.; McFann, Kim; Webb, Tracy L.; Henao-Tamayo, Marcela; Ryan...

Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis Abstract Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail...

Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity Nature, open access: https://www.nature.com/articles/s41467-023-44667-0 Abstract Although many viral infections are linked to the development of neurological disorders, the...

Abstract The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune...

Abstract: Millions globally suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The inflammatory symptoms, illness onset, recorded outbreak events, and physiological variations provide strong indications that ME/CFS, at least sometimes, has an infectious origin, possibly...

Full title: Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection Highlights Tpex cells preserve mitochondrial fitness during chronic infection TGF-β-mediated mTOR-inhibition preserves metabolism in Tpex...

https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1874134 The news article got me interested because of the reference to "restores mitochondiral energy metabolism" Scientists demonstrated that the strength of elite controllers comes from their energy metabolism within CD8 lymphocytes...