Lipophagy confers a key metabolic advantage that ensures protective CD8A T-cell responses against HIV-1, 2020, Loucif et al

Discussion in 'Other health news and research' started by darrellpf, Feb 8, 2021.

  1. darrellpf

    darrellpf Established Member (Voting Rights)


    The news article got me interested because of the reference to "restores mitochondiral energy metabolism"

    Scientists demonstrated that the strength of elite controllers comes from their energy metabolism within CD8 lymphocytes. "Cells require energy, produced in the mitochondria to protect the body and carry out their functions. However, this energy is not used effectively by treated patients. Due to a deregulation of the metabolism, the cells are weakened in their immune function," explains Professor van Grevenynghe, who has worked on HIV for 15 years.

    Re-educating cells

    This energy deficiency is not permanent. Indeed, the research team demonstrated that CD8 lymphocytes can be "re-educated" using a soluble protein that optimizes their energy intake and immune function. "The protein, called interleukin-21 (IL-21), restores mitochondrial energy metabolism through a cell recycling process called autophagy. For elite controllers, the degradation of lipid reserves through autophagy, or lipophagy, is highly effective," explains the Ph.D. student.

    An additional benefit of this breakthrough is that the results of the study would not be limited to HIV-1 alone. "A comparison can be made with other pathologies associated with persistent inflammation, such as cancer, diabetes and even COVID-19 with lung inflammation," notes Julien van Grevenynghe.
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  2. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    For those of us who didn't know what an 'elite controller' is:
    (I think there's a joke somewhere there about the elite controller being the Fat Controller (through lipophagy), but I'm too tired to work out what it is. Or perhaps there isn't. )

    Screen Shot 2021-02-09 at 8.00.17 PM.png
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  3. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    I can't access the paper. But it's interesting to see this in darrellpf's post,
    A very recent study that looked at cytokines in 34 POTS patients found that they had high levels of IL-21.
    Inflammatory Biomarkers in [POTS] with Elevated G-Protein-Coupled Receptor Autoantibodies, 2021, Gunning, Grubb et al
    Last edited: Feb 9, 2021
    Andy likes this.
  4. butter.

    butter. Senior Member (Voting Rights)

    That is because me/cfs is a mitochondrial disease.

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