cd4/cd8

Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function Molly S. George; Jenifer Sanchez; Christina Rollings; David Fear; Peter Irving; Linda V. Sinclair; Anna Schurich Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T...

Introduction: Many people with long COVID symptoms suffer from debilitating neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro-PASC are widely documented, it is still unclear whether PASC symptoms impact virus-specific immune responses. Therefore, we...

Neurology, Neuroimmunology & Neuroinflammation Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection Abstract Background and Objectives SARS-CoV-2 infection has been associated with a syndrome of long-term neurologic sequelae that is poorly characterized. We aimed to...

Abstract Long COVID (LC), a type of post-acute sequelae of SARS-CoV-2 infection (PASC), occurs after at least 10% of SARS-CoV-2 infections, yet its etiology remains poorly understood. Here, we used multiple omics assays (CyTOF, RNAseq, Olink) and serology to deeply characterize both global and...

Hi, is anyone able to comment on these T-cell subset results please? Patient is 11yo, first blood was taken 6 weeks after an exacerbation of symptoms (head lice/histamine) but before PENE, second blood was taken 3 days after taking an antihistamine. Is there anything at all here of note? Are...

Does anyone have a reference to what an inverted CD4/CD8 ratio can indicate (0.7 to 0.8 consistently). Naive CD4 % is normal, but naive CD8 % is elevated. All other CD8 components (effector memory, etc. are low). I have only read that it indicates an “unstable” or impaired immune system, or...