autoantibodies

Team from Germany Abstract The objective of this study was to assess the frequency of IgG autoantibodies in patients with fibromyalgia syndrome (FMS), to characterize their binding to dorsal root ganglion (DRG) neurons and glial cells, and to assess whether specific DRG binding patterns...

Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia Fibromyalgia syndrome (FM) is characterized by widespread pain and fatigue. People living with FM also experience tactile allodynia, cold-evoked pain, paraesthesia and dysaesthesia. There is evidence of small...

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to...

Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice Abstract Approximately 30% of long COVID patients still experience neurological symptoms (brain fog, pain, chronic fatigue) more than 4 months after the...

Autoantibodies against type I interferons are a prominent feature in SARS-CoV-2 fatal disease and hospitalization Rebeca Linhares Abreu Netto, Catherine Chen, Victor Irungu Mwangi, Carlos Eduardo Padron de Morais, Mariana Simão Xavier, Luiz Gustavo Gardinassi, Emily Marie Eriksson, Nicholas...

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how near-universal exposure to the same pathogen can lead to either effective or...

Do self-perpetuating B lymphocytes drive human autoimmune disease? Jonathan C W Edwards, Geraldine Cambridge, Vikki M Abrahams Published: 1999 [Line breaks added] Abstract Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are...

Functional Autoantibodies Targeting G-Protein-Coupled Receptors and Their Clinical Phenotype in Patients with Long-COVID Long-COVID (LC) is characterized by diverse and persistent symptoms, potentially mirroring different molecular pathways. Recent data might offer that one of them is mediated...

Long COVID is associated with female sex; Anti-NCAM1 autoantibodies are absent in patients with long COVID Yukiko Motokawa, Jun Sugihara, Tomoya Tateishi, Tadashi Hosoya, Shinsuke Yasuda, Yasunari Miyazaki, Hidehiko Takahashi, Hiroki Shiwaku [Line breaks added] Background Long COVID is a...

This is disapointing… …"This implies that experience of trauma and distress might elicit a specific immune-biological response in genetically or otherwise (eg, past infection, toxicity, trauma) vulnerable individuals, which includes the production of harmful noninflammatory autoantibodies." …...

Serum antineuronal antibodies in patients with post-COVID-19 condition − association to intensive care Tatiana Posharina, Mikko Varonen, Hanna Jarva, Mari Kanerva, Helena Liira, Sini M Laakso [Line breaks added] Highlights • Antineuronal antibodies found in 12.1% of post-COVID-19 patients...

Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive Berwick, Richard J.; Sahbaie, Peyman; Kenny, Grace; Guo, Tian-Zhi; Neiland, Harvey; Andersson, David A.; Clark...

Immunotherapies for Postural Orthostatic Tachycardia Syndrome, Other Common Autonomic Disorders and Long COVID: Current State and Future Direction Blitshteyn, S., Funez-dePagnier, G., Szombathy, A., & Hutchinson, M Abstract Postural orthostatic tachycardia syndrome (POTS), neurocardiogenic...

Introduction: Following the shift of SARS-CoV-2 from pandemic to endemic, post COVID syndrome (PCS) joins the list of already known post-acute infection syndromes (PAIS) and its most severe manifestation, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The exact pathomechanism of...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

Highlights •FM patients have higher anti-SGC IgG levels associated with pain intensity •FM patients have lower levels of phospholipid classes, sphingomyelin, and triglycerides •FM patients have higher levels of diglycerides •FM severe have higher levels of some lysophosphatidylcholines than FM...

Abstract: Post-COVID syndrome (PCS) has emerged as a significant health concern with persisting symptoms. A subset of PCS patients develops severe myalgic encephalomyelitis/chronic fatigue syndrome (pcME/CFS). Dysregulated autoantibodies (AABs) have been implicated in PCS, contributing to immune...

Association Between NK Cell Genetic Variants and the Development of Long COVID Associated- and Prepandemic Small Fiber Neuropathy Marianne Graninger; Verena Endmayr; Laura M. Kühner; Sarah M. Berger; Paulus Rommer; Sigrid Klotz; Ellen Gelpi; Hannes Vietzen; Romana Höftberger; Elisabeth...

Autoantibodies, Polymorphisms in the Serotonin Pathway, and Human Leukocyte Antigen Class II Alleles in Chronic Fatigue Syndrome Oscar-Danilo Ortega-Hernandez, Mariaclara Cuccia, Sara Bozzini, Nicola Bassi, Samuel Moscavitch, Lina-Marcela Diaz-Gallo, Miri Blank, Nancy Agmon-Levin, Yehuda...

Preprint Link to published paper here ** The Lancet: Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated B2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study Abstract Background: Since the pandemic, SARS-CoV-2 has become the leading trigger for ME/CFS...