acetylcholine

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures Huanhuan Li; Minh C. Pham; Jinfeng Teng; Kevin C. O’Connor; Colleen M. Noviello; Ryan E. Hibbs Skeletal muscle contraction is triggered by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

Full title: Repurposing Duloxetine as a Potent Butyrylcholinesterase Inhibitor: Potential Cholinergic Enhancing Benefits for Elderly Individuals with Depression and Cognitive Impairment Abstract Despite the advent of new treatment strategies, cholinesterase inhibitors (ChEIs) are still the...

Neuro-intestinal acetylcholine signalling regulates the mitochondrial stress response in Caenorhabditis elegans Cornell, Rebecca; Cao, Wei; Harradine, Bernie; Godini, Rasoul; Handley, Ava; Pocock, Roger Neurons coordinate inter-tissue protein homeostasis to systemically manage cytotoxic stress...

Broadening the Genetic Spectrum of Painful Small-Fiber Neuropathy through Whole-Exome Study in Early-Onset Cases Misra, Kaalindi; Ślęczkowska, Milena; Santoro, Silvia; Gerrits, Monique M.; Mascia, Elisabetta; Marchi, Margherita; Salvi, Erika; Smeets, Hubert J. M.; Hoeijmakers, Janneke G. J...

Hi everyone! I haven’t posted here before but have learnt a lot from reading in the past few years - so thank you! (And please say if I’ve posted anything wrongly, hoping I haven’t!) I’m hoping for some help on a couple of questions revolving around acetylcholine. Quick background: I...

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome T. Pietrangelo; R. Mancinelli; L. Toniolo; G. Montanari; J. Vecchiet; G. Fanò; S. Fulle Chronic fatigue syndrome (CFS) is a disabling condition characterized by unexplained chronic fatigue that...

Role of the complement system in Long COVID Vadim Farztdinov; Boris Zuehlke; Franziska Sotzny; Fridolin Steinbeis; Martina Seifert; Claudia Kedor; Kirsten Wittke; Pinkus Tober-Lau; Kathrin Textoris-Taube; Daniela Ludwig; Clemens Dierks; Dominik Bierbaum; Leif Erik Sander; Leif Gunnar Hanitsch...

Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery disease. Filip Mjörnstedt; Rebecka Wilhelmsson; Marcus Ulleryd; Maria Hammarlund; Göran Bergström; Anders Gummesson; Maria E Johansson BACKGROUND The...

Acetylcholinesterase enzyme among cancer patients a potential diagnostic and prognostic indicator a multicenter case–control study Ahmed, Gasmelseed Y.; Osman, Ahmed A.; Mukhtar, Ahlam Acetylcholinesterase enzyme (AChE) activity is impaired by a variety of inhibitors including organophosphorus...

SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck Tommy S. Tillman; Qiang Chen; Vasyl Bondarenko; Jonathan A. Coleman; Yan Xu; Pei Tang A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune...

Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients Lekova, Eleonora; Zelek, Wioleta M.; Gower, David; Spitzfaden, Claus; Osuch, Isabelle H.; John-Morris, Elen; Stach, Lasse; Gormley, Darren; Sanderson...

Reduced Fatigue Symptoms in the Post-COVID Syndrome With Amifampridine: A Collective Casuistry With Double-Blind Discontinuation Trials Abstract After a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, approximately 10-20% of patients are affected by the post-COVID...

Complement in neurological disorders and emerging complement-targeted therapeutics Dalakas, Marinos C.; Alexopoulos, Harry; Spaeth, Peter J. The complement system consists of a network of plasma and membrane proteins that modulate tissue homeostasis and contribute to immune surveillance by...

Abstract Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is an intestinal disorder that causes prolonged inflammation of the gastrointestinal tract. Currently, the etiology of IBD is not fully understood and treatments are insufficient to completely cure...

Enhanced sensitivity of the peripheral cholinergic vascular response in patients with chronic fatigue syndrome Vance A Spence; Faisel Khan; Jill J.F Belch Patients with chronic fatigue syndrome have a variety of clinical symptoms, with associated physical, psychological, and social disability...

Abstract Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule identified. ACh signalling in the neuronal cholinergic system has long been known to regulate numerous biological processes (reviewed by Beckmann and Lips). In actuality, ACh is a ubiquitous...

Abstract Objective Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disorder characterized by debilitating fatigue accompanied by pain and impairments in memory, cognition, and concentration. Acetylcholine (ACh) has a plethora of roles in neuronal and neuromuscular transmission...

Abstract The aetiology of chronic fatigue syndrome (CFS) remains controversial and a number of hypotheses have been put forward to explain it. Research into the condition is hindered by the considerable heterogeneity seen across patients but several reports have highlighted disturbances to...

Summary Although the aetiology of chronic fatigue syndrome (CFS) is unknown, there have been a number of reports of blood flow abnormalities within the cerebral circulation and systemic blood pressure defects manifesting as orthostatic intolerance. Neither of these phenomena has been explained...