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Merged thread Tam’s journey began with one of her family medicine patients in 2015. She couldn’t figure out what was causing their persistent fatigue, which was debilitating enough to keep them out of work. Tam said her patient ultimately had to seek that answer across the country...

Diagnosing dysautonomia is often partly a process of elimination. It also involves determining how and when symptoms occur and finding patterns that connect them. It could be caused by many other issues that haven't been diagnosed that brings on fatigability.

Being upright for too long brings on head pressure. It's related to OI in my experience. I also feel head pressure during delayed PEM but it feels more like a clamp wrapped around my forehead.

The team followed up on this finding with an exhaustive series of experiments encompassing protein-on-protein reactions, human and animal cell lines, lab models, and tissue and fluid samples from COVID-19 patients. This is the picture that emerged: When the coronavirus enters a cell of the...

The researchers began with two related core questions: Why is so little inflammation seen with SARS-CoV-2 in lung cells? And, for the people who don't recover in the first seven to 10 days, why do the symptoms get so much worse They started by screening all SARS-CoV-2 proteins to see which ones...

In lab experiments, the researchers identified a drug that quelled inflammation in human immune cells infected with SARS-CoV-2 and reduced symptoms in mice, suggesting that it may be possible to prevent deadly cytokine storms.

There are two stages that work through different signaling pathways. With the normal pathway, everything goes normally, and the virus replicates. When the immune cells pick up the virus, replication is defective, but it produces a lot of cytokines.

A 2nd pathway the virus sometimes takes to enter immune cells. This alternative pathway both stunts virus's ability to reproduce & prevents production of the 2nd immune signal-braking protein. The 1st protein is then able to spur rampant inflammation linked to severe symptom

The team found that when SARS-2 infects its first-phase targets, cells in the lining of lung, two viral proteins circulate within those cells—one that works to activate the immune system & a 2nd that, paradoxically, blocks that signal, resulting in little or no inflammation

Why SARS-CoV-2 elicits mild symptoms at first but then, for a subset of patients, turn potentially fatal a week or so after infection? A recent study showed that distinct stages of illness correspond with the coronavirus acting differently in 2 different populations of cells.

Abstract Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2-dependent and -independent entries of SARS-CoV-2 in epithelial cells versus myeloid cells dictate viral...

There was an outbreak of EBV in my area in 1991 and 15 separate people in the same neighbourhood developed MS. I developed M.E in 1991.

Conclusion In patients with ME/CFS, various studies have yielded inconclusive results regarding changes in the gastrointestinal processes where microbiota is involved. Whether these divergent findings are due to different molecular phenotypes of patients with ME/CFS remains speculative...

Full Title Complete remission with histamine blocker in a patient with intractable hyperadrenergic postural orthostatic tachycardia syndrome secondary to long coronavirus disease syndrome, 2024, Gonzalez-Alvarez et al Abstract The COVID-19 pandemic caused by the novel severe acute respiratory...

Abstract Implantable sensors can directly interface with various organs for precise evaluation of health status. However, extracting signals from such sensors mainly requires transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increases the risks of infection...

Naturopathic doctors aren't the solution to primary care: doctors, health experts Amid a family doctor shortage in Canada, many naturopathic doctors position themselves as a solution, arguing that they have the training to be a patient’s primary care provider. That’s raising alarm among...

Caffeine gives me a short boost but I feel an exhaustion 3 hours later. On days that I drink coffee I'm unable to do my walking routine in the evening

Merged thread Landmark Study Confirms Chronic Fatigue Syndrome Is 'Unambiguously Biological' News but not new news https://www.sciencealert.com/landmark-study-confirms-chronic-fatigue-syndrome-is-unambiguously-biological

A synthetic ERR agonist alleviates metabolic syndrome, 2024 https://pubmed.ncbi.nlm.nih.gov/37739806/

It's back in the news again. Scientists in the US claim to have boiled down some of the health benefits of exercise into a swallowable pill. The novel drug is in the very early stages of development, but in initial experiments on rodents, the medicine appears to tap into a natural metabolic...