It's back in the news again. Scientists in the US claim to have boiled down some of the health benefits of exercise into a swallowable pill. The novel drug is in the very early stages of development, but in initial experiments on rodents, the medicine appears to tap into a natural metabolic pathway usually triggered by exercise. When administered to mice daily, the drug, called SLU-PP-332, seems to improve muscle function, fitness, and endurance – all without the animals having to move more than they're used to. Presenting the latest results at the American Chemical Society's 2024 Spring meeting, principal investigator and chemist Bahaa Elgendy from Washington University claims that he and his team have succeeded where others have failed. https://www.sciencealert.com/new-exercise-pill-could-induce-fitness-benefits-without-exercise
A synthetic ERR agonist alleviates metabolic syndrome, 2024 https://pubmed.ncbi.nlm.nih.gov/37739806/
It would be interesting to know (but risky) if people with ME took this drug would it induce PEM without exercise.
is it from the drug itself, or the extra activity the stimulant 'cons' you into doing? If its the drug itself & thats common, would that give us insight into mechanisms? I know all stimulants are risky for me, even caffeine, but thats becauce they prevent symptom contingent pacing & make me feel like i'm better than i am... & thus i do much more than i am really able to (without major payback) which causes huge but unexpected crashes/PEM
It's the drug itself. I'm at the point where I'm too sick to do anything, I get pem just from the stimulation.
Caffeine gives me a short boost but I feel an exhaustion 3 hours later. On days that I drink coffee I'm unable to do my walking routine in the evening
