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What about nortriptyline? Does that have the same interactions? Antiepileptics work for some. Topical magnesium (magnesium malate is supposed to be good for pain) is supposed to help, including Epsom salt baths. The ME/CFS Primer says: Duloxetine Milnacipran Tricyclics Tramadol There's also...

Yes, I pointed out how cult-like the LP crowd are on Facebook. Wonder if that'll remain...

Still, it's all rather tacky, isn't it?

Also, yes, a poll might help, but I'm pretty sure most people will prefer a neuroimmune categorisation than a 'functional' one. I do wonder if many of the more severe ME patients instead get an atypical MS diagnosis, since neurologists don't usually expect to see CNS damage in ME (despite some...

MS also has bladder and GI issues, too, of course, so there is overlap. It's more about the modelling of aetiology and pathology. My partner's mother has MS, and our symptoms are so similar. One big difference is that her remission periods are very clear and distinct, whereas we with ME seem to...

I wrote this in a comment the other day but deleted it before publishing because of Godwin's Law. It's also the motto behind PACE, I feel.

All pretty standard salaries. If anything, they're low for the South.

Good lad. I'm ashamed to see this is in my home town.

Tuller, every time!

Yes, I know, I've seen the comparisons. I wasn't saying ME is identical to MS, I'm just wondering whether other people agree that they're essentially the same type of illness. Byron Hyde, for instance, puts ME, MS and post-polio syndrome together. The 'functional' crew put ME, FM and IBS...

Exactly. Any food can be bad in excess. Like you, I keep my carbs low-ish, but I enjoy dark chocolate, the odd drizzle of honey, and a spoonful or two of muesli in my coconut yoghurt. I can still maintain the cognitive perks of ketosis (for me, it reduces brain fog and stops the huge swings in...

This is a few years old, but really highlights the similarities between these two illnesses (and thus makes the difference in treatments more stark). Does anybody with any understanding of the specifics here have any comments? What do we think: is ME like MS? Certainly, the early literature...

This study by Maes and Morris compares the two illnesses well: https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-205 The overlap is incredible.

I get muscle weakness and I do have ptosis in my left eye. However, when they did the antibody test for acetylcholine, it was negative. This was before my ptosis, though. I would say my muscle weakness is worse than my fatigue. But then, early accounts of ME stress 'muscle fatiguability' over...

Things might just be looking up!

People have said this before, but CPET can make patients worse, which is why it isn't used more widely.

It's interesting to me that 30% had this finding. This number has appeared in other studies. Jared Younger has also said he's spotted three subgroups of roughly equal size (autoimmune, post-viral, metabolic). Maybe it'll give us some clues about where to look next, at least? Or maybe we can...

If they use Fukuda, they need to stratify for CCC or ICC too. I simply don't believe that looking at a more heterogeneous patient group will provide meaningful answers unless you then split the patients up by criteria. Inconclusive results from too-broad criteria don't seem to be giving us clues...

This is exactly what we need from a researcher. He's definitely right about the language used. If anything, it's an hysterical, catastrophising kind of monologue that says more about the people who use it than patients. The message is: 'This illness is a baffling, horrible mystery beset my...

I like VanElzakker. His 'vagus nerve hypothesis' is certainly interesting, and would tie together a few existing studies: https://www.ncbi.nlm.nih.gov/m/pubmed/23790471/ He's following up on the Japanese PET study, albeit to take things in a slightly different direction. Though, I suspect, as...