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Background The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods This prospective cohort study recruited adults who had survived hospitalisation with clinically diagnosed COVID-19 across 35 sites in the UK...

BACKGROUND: Myalgic encephalomyelitis (ME) is a complex, multi-system neurological condition. The defining feature of ME is post-exertional malaise (PEM) with over 30 symptoms triggered by physical, cognitive, emotional and social activity. The cause of PEM is unclear but one area of research...

BACKGROUND: Existing instruments often are inappropriate to measure the effects of post-exertional malaise (PEM) and post-exertional symptom exacerbation (PESE) on activities of daily living (ADLs). A validated questionnaire to measure self-reported ability with ADLs would advance research and...

BACKGROUND: Post-exertional malaise (PEM) is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) yet its diverse manifestations make it difficult to recognize. Brief instruments for detecting PEM are critical for clinical and scientific progress. OBJECTIVE: To...

Preprint. Paper now published, see this post Abstract A blood-based diagnostic test for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS) would be of great value in both conditions, facilitating more accurate and earlier diagnosis, helping with current...

An alternate suggestion that we have been using to help with noise from other flats is a white noise generator. Lots of options out there, and perhaps might not be suitable for your situation, but we have found that it definitely helps to make noise from elsewhere less disturbing to us.

More from the post that John Mac linked to

Published papers thread for w/c 13th March. Facebook: https://www.facebook.com/sci4me/posts/pfbid02mSFyuTg5gVhdykEj1nTTGRjodWmfyyeU7HYUYtsmcT9XQ7c3YVyvk1NsAVdXwSo7l Mastodon: https://med-mastodon.com/@s4me/110055051421628426

News in Brief posts for w/c 13th March. Facebook: https://www.facebook.com/sci4me/posts/pfbid0CuewzMtTgxAkPSqpBLtetkbYeQ3fpHVp2cU3i4sofrnmpXv4EhEWvfGXBxVu6zDMl Mastodon: https://med-mastodon.com/@s4me/110050102951042269

Highlights Limited treatment options exist for patients with functional neurological disorders. Psychotherapeutic treatments show encouraging results for FND in research settings. A limited number of published studies explore motor and seizure FND outcomes in the natural outpatient clinic...

Several major epidemiological studies have been funded in the UK with the goal of better understanding the epidemiology of persistent symptoms following SARS-CoV-2 infection. Investigators from nine of these studies formed the National Long COVID Research Working Group in 2021 to share key...

"4.2 Characterization of exhaustion disorder Demographic and clinical data collected from ED-participants through closed-ended questions and symptom questionnaires in the present study indicate a clinical picture that is similar to findings from previous qualitative and quantitative inquiries...

"Given the substantial societal impact of chronic stress and fatigue, there is a need for further investigation into symptom presentation, diagnostic characterization, and steps towards standards regarding outcome domains to measure in clinical trials. Indeed, a recent review of all published...

"In response to increasing sick leave rates due to mental disorders in the late 1990's in Sweden, together with clinical observations that many sick-listed individuals reported prolonged exposure to psychosocial stressors and symptoms of fatigue, tentative criteria for a new diagnosis...

Diagnostic Criteria for exhaustion disorder (ED) (F43.8 A) A. Physical and mental symptoms of exhaustion during at least 2 weeks. The symptoms have developed in response to one or more identifiable stressors, which have been present for at least 6 months. B. Markedly reduced mental energy...

Apologies if I'm duplicating anything but I wonder if what they did in this study might have some relation to Dr Alan Moreau's new, low-stress protocol for provoking PEM.[Thoughts?], which also involves an arm pressure cuff. The thought was inspired by spotting this, Preprint: Altered Tissue...

For published version see Altered tissue oxygenation in patients with post COVID-19 syndrome (2023, Microvascular Research) ******************** Pre-Print https://www.researchgate.net/publication/369239099_Altered_Tissue_Oxygenation_in_Patients_with_Post_COVID-19_Syndrome Background: Post...

Objective Sleep disturbance may constitute health problems for the afflicted individual, but documentation of its chronicity is sparse. The objective was to investigate the extent to which incident and chronic sleep disturbance are associated with stress, mental ill-health and functional somatic...

Abstract Objectives Post-acute sequalae of SARS-CoV-2 infection (PASC) is not well defined in pediatrics given its heterogeneity of presentation and severity in this population. The aim of this study is to use novel methods that rely on data mining approaches rather than clinical experience to...

Background Intravenous immune globulin (IVIg) is frequently used in some neurological diseases and is also the first-line therapy in Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. We aimed to evaluate the frequency and characteristics...