Xolair (omalizumab) comments (and relation to any proposed mechanisms of m.e.)

as a very rough tldr, for anybody wondering, of my very rough and probably wrong understanding of it, it works via a rituximab-like mechanism, except against ige. it also affects basophils and mast cells.
it is used for allergy-like / histamine-like conditions. even nasal polyps.

side-effects include clotting [perhaps because mast cells release heparin? idk]. apparently being bedridden is also a risk for clotting, and compression stockings are recommended. others are also mentioned, but apparently a couple of debunked side effects are on the label.


question 1: does anybody have any comments on this medicine? in general, or for very severe m.e., or for extremely severe m.e., or for angioedema, either histaminergic or not, or for a highly allergic or mold injury presentation, or for an mcas-like presentation [tryptase being -.]?

well-known, theoretical, practical, speculative, personal experience, anecdotal, all are ok. looking for any comments you might have.


mast cells can release lots of stuff, so perhaps it is useful for anything related to them also? e.g. if il-8 and il-6 are high, could it reduce them and if so would that potentially have any effect on m.e.? one il-6 or il-8 reducer was considered for m.e. once.


also i have heard recently only the briefest indication that the innate immune system is being investigated, a shunt or + feedback state?

so my question 2 includes, do you have any comments on whether this medicine could affect, negatively or positively, future or studied treatments, by e.g. changing the innate immune system state or something similar?


question 3 is, would it at least theoretically be good or bad while administered while a moldie is further mold-injured?


question 4 is, 2nd-generation antihistamines cetirizine and fexofenadine can help sleep. could this med in principle act to promote sleep, in addition to potentially obviating the need for antihistamines' anti-allergy / mast cell properties?