Hi there, short explanation of my symptoms. I am not the typical "got ME after virus" patient, it came on more gradually. I am now suffering from adrenal dysfunction, mast cell activation disorder not officially diagnosed, but must be sth like that with feelings of much histamine, insomnia, feeling like poisoned/inflammed all over, flu like limb pain, cortisone and ibuprofen help with inflammation, but thats nothing for every day use (described inflammation symptoms triggered from excertion, so every step I do triggers a reaction, but this doesnt feel like typical PEM), never got sick since it all started, gastroparesis and neuropathy in legs (both started the same day!), heat intolerance, mostly housebound, most of the time in bed. Extreme muscle weakness in thighs, constant cramping/fasciluations. Started same day as gastroparesis and neuropathy. My familiy doctor is nice but does not support any testing, tells me just to deal with it. Rheumi not helpful either as he ruled out classical diseases 2 years ago. I have elevated ANA 1:160, he considers everyting below 360 as harmless. I have the strong impression there is autoimmunity involved that attacks my nervs and the mastcells. I cannot tolerate mcas medications as these all come along with some anticholinergic side effect and this aggravates my gastroparesis (which lead me to the conclusion that acetylcholine must be involved in that). Where to start? I will probably retest my ANA titers. I will test the ganglionic acetylcholine-antibodies Probably anti phospholipid antibodies anti calcium antibodes Any suggestions? I have to pay all tests on my own. Thank you!