Opinion What Long COVID investigators can learn from four decades of ME/CFS research, 2023, Jason et al

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https://www.sciencedirect.com/science/article/pii/S2949834123000211

Brain Behavior and Immunity Integrative
Volume 4, December 2023, 100022

What Long COVID investigators can learn from four decades of ME/CFS research

Leonard A. Jason a,* , Benjamin H. Natelson b , Hector Bonilla c , Zaki A. Sherif d , Suzanne D. Vernon e , Monica Verduzco Gutierrez f , Lisa O’Brien g , Emily Taylor h , On behalf of the RECOVER consortium, by members of the Diagnostic Testing and Test Algorithms Subcommittee of the Commonalities with Other Post Viral Syndromes Task Force. We appreciate the edits and suggestions from Ben Z. Katz

https://doi.org/10.1016/j.bbii.2023.100022Get rights and content


Abstract


Four decades of research in the field of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have yielded lessons that may be instructive for those devising criteria to better comprehend Post-Acute Sequelae of SARS CoV-2 Infection (PASC) and Long COVID.

For instance, substantial effort has been devoted to defining classification systems, operationalizing methods, and developing instruments with adequate reliability and validity in the ME/CFS field.

The current article provides guidelines for developing a case definition for Long COVID and discusses the significance of psychometric issues and criterion variance, including how to specify symptoms, develop thresholds, subtypes, and exclusionary conditions.

ME/CFS research could enhance our knowledge of Long COVID pathophysiology, early diagnosis, prognosis, and the identification of effective treatments.

 
Natelson et al. (2007) discovered that hypocapnia (blood CO2 deficiency) is a biomarker for orthostatic intolerance in ME/CFS. Using capnography (concentration or partial pressure of carbon dioxide in respiratory gases), hypocapnia is diagnosed if more than one reading of 32 mmHg or less is recorded during the active standing portion of the examination.

? I think this is overstating? Never heard of this study.

Natelson seems to be an author of this opinion piece as well.
 
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