Local brain infection with virus would normally show up clearly on an MRI scan. Based on what we know of documented brain infection I think it is vanishingly unlikely in ME. I think much the most likely reason that people improve while taking antiviral is that it is nothing to do with the drug. Antiviral drugs are very unlikely to do anything else of interest. I know that such ideas have been raised but not with any plausible basis I know of. The one thing that disappointed me about Jen Brea's film was that the tiny bit of 'science' seemed muddled, speculative and out of date. There is no immunodeficiency to let viruses react I ate as far as we know. There are no inflammatory cytokines flying around. I think now we have evidence from lots of good research groups it is time to move on from this approach.