Opinion What are the top replicated ME/CFS findings?

Might it also be useful to mention the issue Jonathan has talked about, where it's possible some negative studies did look at the right thing, just not in the right place?

If the error is very localised the odds are stacked heavily against finding it, especially when those doing the looking tend to be small teams relying on blood samples for their experiments.

 

I found this review on NK cell disfunction in ME.

https://pubmed.ncbi.nlm.nih.gov/31727160/

Is this robust enough to speak of NK cell disfunction in ME?

Honest question, do not have a science background.

Edit; and if not, what would it need to become more of a robust finding?

 

Not really. Even if their findings are representative they might be showing NK cells showing reduced function in response to something like TGF beta. The NK cells may be fine.

NK assays are notoriously difficult to interpret. It is hard to see what relevance sleepy NK cells would be to ME/CFS symptoms even if they are sleepy.

 

Thank you Mr Edwards, for the explanation.