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Webinar - ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study - Jarred Younger

Discussion in 'BioMedical ME/CFS News' started by MeSci, Nov 16, 2018.

  1. alex3619

    alex3619 Senior Member (Voting Rights)

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    Yes. Its not explained. A mistake? A major clue? Secondary to brain inflammation? We need to know.
     
  2. Inara

    Inara Senior Member (Voting Rights)

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    I have read a bit about fractalkine.

    Fractalkine seems to play a neuroprotective and an inflammatory role.

    Here, https://www.nature.com/articles/nn0706-859 the authors show:
    For this, the authors ablated the fractalkine receptor (which sits on microglial cells). Other papers show or discuss the neuroprotective role in Alzheimer's disease and Parkinson's. E.g., decreased levels of fractalkine seem to indicate a higher severity or progression of the disease.
    (E.g. https://www.ncbi.nlm.nih.gov/pubmed/26084002; in the retina: https://www.ncbi.nlm.nih.gov/pubmed/28216676)

    In people with ME, a small study found decreased levels of fractalkine.
    https://www.ncbi.nlm.nih.gov/pubmed/26615570

    So it could be that activated microglial cells and decreased fractalkine are not contradictory.
     
  3. Andy

    Andy Committee Member & Outreach

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    Webinar is now available on YouTube
    Code:
    https://youtu.be/rxdzaWD5wfU
     
    Hutan, MeSci, rvallee and 3 others like this.

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