Discussion in 'BioMedical ME/CFS News' started by MeSci, Nov 16, 2018.
Yes. Its not explained. A mistake? A major clue? Secondary to brain inflammation? We need to know.
I have read a bit about fractalkine.
Fractalkine seems to play a neuroprotective and an inflammatory role.
Here, https://www.nature.com/articles/nn0706-859 the authors show:
For this, the authors ablated the fractalkine receptor (which sits on microglial cells). Other papers show or discuss the neuroprotective role in Alzheimer's disease and Parkinson's. E.g., decreased levels of fractalkine seem to indicate a higher severity or progression of the disease.
(E.g. https://www.ncbi.nlm.nih.gov/pubmed/26084002; in the retina: https://www.ncbi.nlm.nih.gov/pubmed/28216676)
In people with ME, a small study found decreased levels of fractalkine.
So it could be that activated microglial cells and decreased fractalkine are not contradictory.
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