Video: New insights into CFS and ME : Prof Wirth, Patrick Ussher

Sly Saint

Sly Saint

Senior Member (Voting Rights)
I'm not sure where this should go, or to be honest what exactly its about.
The host is a cardiologist who's videos on blood pressure I have watched.
However this is not a direct cardiology related video.
The only notes are:
To follow Prof Wirth’s ME/CFS drug in development: www.mitodicure.com Patrick’s book ‘Understanding ME/CFS & Strategies for Healing’ https://www.amazon.com/dp/2959831004?...Patrick’s YouTube channel / @me-cfs-strategiesforhealing And all other links https://linktr.ee/patrickussher'
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I am not familiar with either of the people he is interviewing, but I'm sure some here is.

He starts by interviewing Professor Wirth who references the research done at the Charite by Scheibenbogen.

The book at the Amazon link is by Patrick Ussher; one review reads:
Excellent book has finally helped me to understand the "stranger's body" | now inhabit. One Covid infection has led to a Long Covid and ME diagnosis. Myalgic encephalomyletitis is not a new illness- but it is understudied and funded. Patrick Ussher speaks from his own experience as an ME/CFS patient researcher. Heavily
influenced by the work of Wirth and Scheibenbogen- he describes this as an illness of global hyper perfusion. When I began reading the book, I could not understand that term. I spent the spring learning from Ussher's book- what is orthostatic intolerance and why am I unable to stand without pain/ malaise? What role does auto immunity play? What is the cause of exercise intolerance? He even tackles the thorny topic of brain retraining- finding benefit in some elements- but clearly stating our illness is not psychosomatic. With a mix of detailed research and plain language summaries- I found this to be incredibly helpful to my healing journey. I will reread it.; like many with long Covid and ME- my memory and cognition is impacted.
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sorry it's all a bit vague!
 
The hypothesis doesn’t seem to be very popular here on the forum, but I bought the book mainly because of the Mitodicure section (about 70 pages). I didn’t read the rest.

I also find the title rather inappropriate and a bit clickbaity.
That said, I find the hypothesis quite interesting, and for people who are interested but don’t have a strong medical background, the material is actually explained quite well. For €2.99, you can’t really go wrong if you just want to learn more about it.

The book also mentions a rat study in which these drugs were apparently tested. I’d be very interested to know whether this study will be published at some point — that would certainly be interesting.
 
Dude said:
The hypothesis doesn’t seem to be very popular here on the forum, but I bought the book mainly because of the Mitodicure section (about 70 pages). I didn’t read the rest.

I also find the title rather inappropriate and a bit clickbaity.
That said, I find the hypothesis quite interesting, and for people who are interested but don’t have a strong medical background, the material is actually explained quite well. For €2.99, you can’t really go wrong if you just want to learn more about it.

The book also mentions a rat study in which these drugs were apparently tested. I’d be very interested to know whether this study will be published at some point — that would certainly be interesting.
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My issue is that Wirth has done no basic research in ME/CFS, has only published hypothesis papers, and has gone straight to drug development. If it turns out to work I'll be over the moon but I can't bring myself to get excited until I see some solid science behind it.

This guy Ussher also promotes brain retraining, and did a video about BC007 where he as good as said it would definitely work before the study came out.
 
Jonathan Edwards said:
Can you tell us what in it is worth €0.99?
I would not want to pay more for some seriously incoherent attempts at science.
I may sound dismissive but that is because i am old and angry that people have been so badly let down by shamateurs.
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It is essentially a reworking of the hypothesis, including the studies that Wirth and Scheibenbogen were involved in, such as “A Unifying Hypothesis of the Pathophysiology of ME/CFS...” and “Microvascular Capillary and Precapillary Cardiovascular Disturbances …”.

The most important and relevant studies supporting the hypothesis are briefly highlighted and summarized again.

One example (without getting into how forum members may have judged it) is the finding of high intracellular sodium levels in ME/CFS, measured in fatigued muscles of ME/CFS patients. These measurements showed that intracellular sodium levels were significantly higher than in a healthy, sedentary control group (30% versus 17%).

There are also a few pieces of information included that have not yet been published, such as a rat study in which patient serum was administered to rats to induce muscle weakness (I’m not sure whether this will eventually be published).

Overall, most of the content is not entirely new, but it is presented in a clearer and more accessible way for laypeople who are interested in the hypothesis.

@Jonathan Edwards
Since you’re not a big fan of Wirth or his hypothesis anyway, you can probably save your money ;-)
 
V.R.T. said:
This guy Ussher also promotes brain retraining, and did a video about BC007 where he as good as said it would definitely work before the study came out.
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Yes, definitely. The guy isn’t really a scientist (which he doesn’t claim to be) but more of a hobby journalist, if I understand correctly. In the book, he often talks about his own experiences with therapies, etc. Even the book title is rather questionable, if you ask me. As I said, I’ve only read the Mitodicure section because it was developed in collaboration with Wirth. I can’t really comment on the rest of the book’s content. But there is actually a section where he expresses disappointment about the outcome of the BC007 study.
 
I posted info on Ussher's book here in 2023

MeSci

Thread 'New book on ME/CFS and polydipsia (excessive fluid consumption and excretion)'

I've just been notified of a book on this subject, which seems to be a common part of ME.

I haven't read it yet.

It's by Patrick Ussher, who, like me, suffers from ME and polydipsia.

It can be downloaded free here: https://www.themythofprimarypolydipsia.com/

Extract:

"The tendency of medicine to suggest that symptoms it does not yet understand are psychosomatic has a long history and one that rarely ages well: Parkinson’s, MS and ME patients, among others, have all had to face this kind of stigma. This book argues that patients with so-called “Primary Polydipsia” fall into the...
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