Video: Figuring Out Long COVID - with Emma Wall, Research Fellow at the Crick, 2025

YouTube Description
Join Emma Wall, a Senior Clinical Research Fellow at the Crick as she explains the science of long COVID, who it affects, its symptoms and how it can be prevented and treated.

Long COVID has affected up to 2% of the entire UK population in the last five years, but we still don’t fully understand this often-debilitating disease.

Emma explains how researchers are finding treatments for this new disease and how it’s important to embrace uncertainty to find solutions.

Emma Wall leads clinical research for the UCLH-Crick partnership on COVID-19. Her team are focused on improving understanding of the biology of long COVID to discover new ways to both prevent and treat this complex disease.
00:00 Intro
02:54 What is long COVID?
07:48 A patient's perspective
10:30 Who can be affected?
13:50 What is the cause?
19:06 Symptoms
23:43 Can it be prevented?
27:44 Treatment
33:07 What's being done?
36:18 Studies and trials
 
16:12 Antibodies transferred from Long Covid to mice caused some symptoms. When they sectioned the mice they found that the antibodies were bound to nerves.

Studies are about to be published on this (currently preprint). Does anyone remember that finding about antibodies binding to nerves?
 
Emma Wall has a presentation at Keystone next month titled 'An Innate Inflammatory Signature Is Consistently Enriched in the Plasma of Adults Living with Long COVID Across all Clinical Symptom Groups'

Long COVID and Other Post-Acute Infection Syndromes | Keystone Symposia

Join us at the Keystone Symposia on Long COVID and Other Post-Acute Infection Syndromes, August 2025, in Santa Fe, with field leaders!
www.keystonesymposia.org www.keystonesymposia.org
 
Nath is also presenting on neurological and vascular damage in long covid - hard to believe after the intramural study's results on 'effort preference'.

Avindra Nath, NINDS, National Institutes of Health
Neurological Complications in Long COVID and ME CFS
 
I watched half of Emma Wall's presentation and was unimpressed. It seemed to be a rag-bag account of all the things we have already heard of and one or two that we may not have but may not tell us much more. There seemed to be no attempt to critique or discriminate. If there is evidence for this many things being wrong then most of that evidence must be redundant and irrelevant. The tired old duo of viral persistence and autoimmunity came up.

The speaker sounded more like a journalist commentator than a scientist should. Yet there were the usual phrases you get from people who like to give an impression of being at the cutting edge: 'we think that...'. Who is we?
 
wigglethemouse said:
Long COVID has affected up to 2% of the entire UK population in the last five years, but we still don’t fully understand this often-debilitating disease.
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Small detail, but for once I'd really like for someone to actually tell the truth: they don't even partially understand anything about it. And as far as I'm aware, nothing that wasn't known 5 years ago, and almost nothing that was known 20 years ago.

Always with the fully, the same dynamic some play with the "not ALL in the head" language. Which could suggest they understand as much as 80% of it, when in reality it's not even 10%. Really small detail but I'm a sucker for language accuracy.
 
Jonathan Edwards said:
I watched half of Emma Wall's presentation and was unimpressed. It seemed to be a rag-bag account of all the things we have already heard of and one or two that we may not have but may not tell us much more. There seemed to be no attempt to critique or discriminate. If there is evidence for this many things being wrong then most of that evidence must be redundant and irrelevant. The tired old duo of viral persistence and autoimmunity came up.

The speaker sounded more like a journalist commentator than a scientist should. Yet there were the usual phrases you get from people who like to give an impression of being at the cutting edge: 'we think that...'. Who is we?
Click to expand...
The first half is a bit of an intro for the general audience, in the second half she walks through the work her group actually does
 
ellesa said:
The first half is a bit of an intro for the general audience, in the second half she walks through the work her group actually does
Click to expand...

And is it of interest? I am not sure I have the time to go back.

Why spend half an hour repeating fashionable memes about LC rather than applying some critical analysis?
 
Jonathan Edwards said:
And is it of interest? I am not sure I have the time to go back.

Why spend half an hour repeating fashionable memes about LC rather than applying some critical analysis?
Click to expand...
It doesn't go into much detail so probably not worth going back to, but she does mention that STIMULATE ICP will be doing a second round of trials and they are planning that now ish

Going by the other videos on that channel the talk series seems to be fashionable memes in general
 
ellesa said:
she does mention that STIMULATE ICP will be doing a second round of trials and they are planning that now ish
Click to expand...

Hm. As far as I can see STIMULATE ICP was an open label study with subjective outcomes that included rehab stuff and some rather implausible drug options.
 
Jonathan Edwards said:
Hm. As far as I can see STIMULATE ICP was an open label study with subjective outcomes that included rehab stuff and some rather implausible drug options.
Click to expand...
Emma Wall said something in the video along the lines of the first round of drugs in STIMULATE ICP being based on 'Toby and I doing some beard stroking in 2021'. There appears to be an attempt to be more targeted in the second round. She also mentions collaborating with PHOSP which has Tocilizumab in trial at the moment.
 
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