Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping, 2024, Lee et al.

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  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping
    Hyunyeol Lee; Jing Xu; Maria A Fernandez-Seara; Felix W Wehrli

    Quantitative BOLD (qBOLD) MRI allows evaluation of oxidative metabolism of the brain based purely on an endogenous contrast mechanism. The method quantifies deoxygenated blood volume (DBV) and hemoglobin oxygen saturation level of venous blood (Yv ), yielding oxygen extraction fraction (OEF), and along with a separate measurement of cerebral blood flow, cerebral metabolic rate of oxygen (CMRO2 ) maps.

    Here, we evaluated our recently reported 3D qBOLD method that rectifies a number of deficiencies in prior qBOLD approaches in terms of repeat reproducibility and sensitivity to hypercapnia on the metabolic parameters, and in comparison to dual-gas calibrated BOLD (cBOLD) MRI for determining resting-state oxygen metabolism.

    Results suggested no significant difference between test-retest qBOLD scans in either DBV and OEF. Exposure to hypercapnia yielded group averages of 38 and 28% for OEF and 151 and 146 mmol/min/100 g for CMRO 2 in gray matter at baseline and hypercapnia, respectively. The decrease of OEF during hypercapnia was significant (p ( 0.01), whereas CMRO 2 did not change significantly (p ¼ 0.25). Finally, baseline OEF (37 vs. 39%) and CMRO 2 (153 vs. 145 mmol/min/100 g) in gray matter using qBOLD and dual-gas cBOLD were found to be in good agreement with literature values, and were not significantly different from each other (p > 0.1).

    Link | PDF (Journal of Cerebral Blood Flow & Metabolism)
     
  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Posting for background for the fMRI findings in Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (2024, Nature Communications).

    From the introduction —

    Screenshot 2024-02-26 at 11.44.34 AM copy Medium.jpeg

     
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    SNT Gatchaman Senior Member (Voting Rights)

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    Concluding —

     
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    SNT Gatchaman Senior Member (Voting Rights)

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