Using deconditioned people as controls

[Kitty]

I'd feel a lot better about such a study if they put activity trackers on everyone for maybe a week to make sure the activity levels are at or below pwME

That's a worthwhile study on its own, to be honest.

 

[Mij]

I guess you could do a study on pwME and controls over the age of 65? There are plenty of sporty older people, of course, but there are also many who're no more active than folk with mild/moderate ME.

This age group would also include some post menopausal women who have had exertion and energy depletion over time due to hormones. The energy depletion is quite significant.