USA: Dr Groysman

[MinIreland]

Hi, a friend of mine recently recommended to look into the work of Dr Robert Groysman. I am not sure what to think of his work so I would like to gather some insights here.

Any informed opinions?

Thanks,!

 

[Peter T]

From the Covid Institute web site

Dr. Robert Groysman didn’t plan to specialize in Long COVID. He was treating chronic pain and PTSD with interventional procedures when he contracted Long COVID.

His symptoms persisted. Traditional medicine had no answers. He could have cycled through specialists, but instead, he did something different: he researched the mechanisms himself.

What he discovered changed everything. Long COVID wasn’t one problem, it was six biological mechanisms creating different combinations in each patient, like a fingerprint.

Dysautonomia. Mitochondrial dysfunction. Endothelial damage and microclots. Gut dysbiosis. MCAS & Excess histamine. Hormonal imbalance.

All interconnected. Often missed by standard testing.

He applied this framework to his own recovery. It worked.

He documented the complete framework in a seven-book series, The Complete Long COVID Handbook, published 2024-2025. Now, at his clinic in Plano, Texas, he offers what he needed when he was sick: answers.

See https://covidinstitute.org/about-dr-groysman/

 

[Peter T]

The site says:

Dysautonomia – Autonomic nervous system stuck in crisis mode are unable to regulate heart rate, blood pressure, digestion, temperature

Mitochondrial Dysfunction – Cellular energy production impaired can trigger profound fatigue even when nutrient levels are normal

Endothelial Damage & Microclots – Microscopic clots can restrict oxygen delivery; standard clotting tests miss these entirely

Gut Dysbiosis – Microbiome imbalance can disrupt the gut-brain axis, serotonin production, and immune function giving birth to symptoms that seem unrelated.

Hormone Imbalance – Persistent inflammation affecting nervous tissue, driving brain fog and cognitive symptoms

Mast Cell Activation – Immune cells releasing inflammatory chemicals inappropriately, causing allergic-type reactions without actual allergens

These mechanisms interact with gut dysbiosis affecting autonomic function, impairing mitochondrial efficiency, contributing to inflammation.

This is why you have cardiac AND neurological AND GI symptoms simultaneously.

See https://covidinstitute.org/

The 6 Mechanisms In Depth

 

[Peter T]

My first ill informed thought was, to quote Alexander Pope:

A little learning is a dangerous thing ;

Drink deep, or taste not the Pierian spring :

There shallow draughts intoxicate the brain,

And drinking largely sobers us again.

 

[Trish]

It doesn't look like anything new. It looks from that diagram like all the usual list of possibilities we have discussed on this forum, none of them yet shown to be the root cause of LC or ME/CFS.

It looks very much like yet another person using their own ancedote for personal gain.
Seven books seems somewhat excessive.

 

[MinIreland]

Hi, a friend of mine recently recommended to look into the work of Dr Robert Groysman. I am not sure what to think of his work so I would like to gather some insights here.

Any informed opinions?

Thanks,!

My first ill informed thought was, to quote Alexander Pope:

A little learning is a dangerous thing ;

Drink deep, or taste not the Pierian spring :

There shallow draughts intoxicate the brain,

And drinking largely sobers us again.

Hmmm. Thanks, @Peter T, I think you're right. Unfortunately. Illustrative anecdote: I saw my doctor yesterday (Dr Rizwan) and I asked him where he gets his information on ME/CFS from. His answer: "From you, my patients." At least it's an honest answer.

My first ill informed thought was, to quote Alexander Pope:

A little learning is a dangerous thing ;

Drink deep, or taste not the Pierian spring :

There shallow draughts intoxicate the brain,

And drinking largely sobers us again.

Hmmm. Thanks, @Peter T

 

[wabi-sabi]

It doesn't look like anything new

And the information that is there is very vague and generic. He lists testing for gut dysbiosis or mitochondrial dysfunction, but doesn't say what tests exactly he runs to determine this. As far as I know, there aren't a lot of tests that determine this reliably in a clinical setting. If you caompare this to a reliable information source, like the stuff from Batmen Horne, or even the old IOM report or the international clinicain guide from years ago, you'll see how lacking this is.

You'd have to be living under a rock or a BPSer not to know about dysautonomia at this point. Dr. Rowe wrote up a whole guide on this and this person surely oes not give me the impression he knows more.