Taking the low-end of $36B per year, with the US representing approx. 20% of the world's GDP means roughly $180B per year (with a high over ~$250B). Obviously economic productivity is not evenly distributed but taking the lowest estimate mostly takes care of that.
That means about $1T every 5-7 years. If we set the clock at the mid-80's, being very generous going with the time medicine paid attention to it, rather than when it should have paid attention to it, we have about 3 decades. That makes it a bare minimum of $4T in wasted economic activity.
The sum total of relevant funding to address this >$4T economic disaster has been about $100M give or take, accounting for the fact that most of that investment was explicitly wasted on fairy tales and that overall investment were so low they were mostly wasted, roughly the same way not putting enough fuel in a rocket will simply see it crash down without reaching orbit.
Not even taking account of the immense human suffering, how many multi-trillion dollar problems exist out there that can be fixed with not much more than $1B in direct annual funding that would eventually cease once breakthroughs solve the problem entirely? In fact fixing most of that problem doesn't even require direct investments, simply ending the state of systemic discrimination would cut it in half, at least once it's put into practice.
Contrary to popular belief, denying chronic illness is not cheap. In fact it may just be one of the single most expensive decisions ever made. Saving pennies out of one pocket only to spend crisp hundred dollaroos out the other is the exact opposite of smart economics.
It's amazing to think that not only are trillions in economic activity wasted entirely, medicine has actually paid money, not much but still, to guarantee that we lose even more in the end. We are literally paying more to lose more. Like a casino where the player never ever wins, but the gambler is completely addicted to the shiny gold stars they give each other so whatever, let's just keep burning the equivalent GDP of large countries while destroying millions of lives. Apparently it's the smart medicine thing to do, or at least it's the BPS way.