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Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia, 2021, Vivek et al

Discussion in ''Conditions related to ME/CFS' news and research' started by Andy, Dec 17, 2021.

  1. Andy

    Andy Committee Member

    Hampshire, UK
    The pathophysiology of fibromyalgia syndrome (FMS) remains elusive, leading to a lack of objective diagnostic criteria and targeted treatment.

    We globally evaluated immune system changes in FMS by conducting multiparametric flow cytometry analyses of peripheral blood mononuclear cells and identified a natural killer (NK) cell decrease in patients with FMS. Circulating NK cells in FMS were exhausted yet activated, evidenced by lower surface expression of CD16, CD96, and CD226 and more CD107a and TIGIT. These NK cells were hyperresponsive, with increased CCL4 production and expression of CD107a when co-cultured with human leukocyte antigen null target cells. Genetic and transcriptomic pathway analyses identified significant enrichment of cell activation pathways in FMS driven by NK cells. Skin biopsies showed increased expression of NK activation ligand, unique long 16–binding protein, on subepidermal nerves of patients FMS and the presence of NK cells near peripheral nerves.

    Collectively, our results suggest that chronic activation and redistribution of circulating NK cells to the peripheral nerves contribute to the immunopathology associated with FMS.

    Paywall, https://journals.lww.com/pain/Abstr...profiling_reveals_a_natural_killer.97873.aspx
    Chezboo, Slamdancin, Lilas and 11 others like this.
  2. Ravn

    Ravn Senior Member (Voting Rights)

    Aotearoa New Zealand
    This study is now open access (via pdf download):

    Cort's write-up:
    Last edited by a moderator: Apr 30, 2022
    Chezboo, Slamdancin, voner and 5 others like this.
  3. voner

    voner Senior Member (Voting Rights)


    thanks for posting those lniks. That is an impressive paper.
    Ravn likes this.
  4. voner

    voner Senior Member (Voting Rights)

    here is one of their conclusions…

  5. rvallee

    rvallee Senior Member (Voting Rights)

    For the biologically uninitiated (like me), wiki:

    Extravasation is the leakage of a fluid out of its container into the surrounding area, especially blood or blood cells from vessels. In the case of inflammation, it refers to the movement of white blood cells from the capillaries to the tissues surrounding them.​
    NelliePledge, Milo and voner like this.

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