Tutorial: The Practical Application of Longitudinal Structural Equation Mediation Models in Clinical Trials (2017) Chalder et al

https://www.ncbi.nlm.nih.gov/pubmed/29283590
http://psycnet.apa.org/fulltext/2017-57776-001.pdf

 

Oh dear I think they should stay away from stats. From what I remember with the PACE mediation model they failed to model important temporal aspects. Also I seem to remember that the scales they use broke the basic assumptions of the methods.

But mediation models as whole seem to be a bad idea trying to replace complex methods and corrections with trying to use the stats to gain an understanding of the basic system. David Freedman wrote a good article "statistics and shoe leather" with the point being:
https://web.math.rochester.edu/people/faculty/cmlr/Advice-Files/Freedman-Shoe-Leather.pdf
"Statistical techniques can seldom be an adequate substitute for good design, relevant data, and testing predictions against reality in a variety of situations"

It seems like they use mediation analysis to cover for having an untestable hypothesis and bad data (subjective measures in a trial aimed at changing subjective feelings of symptoms).

Still I may have a read as I was thinking of looking at mediation analysis for a data prediction problem.

 

And now they want to teach other researchers how to do the same!

 

For crying out loud. Is the PACE team going to teach us about Structural Equation Models? Embarrassing. Their analysis uses subjective outcomes and excludes all biomedical factors. Talk about begging the biopsychosocial question.

Any expert in the field could explain for Goldsmith et al. that you cannot prove causality from SEMs. They can be used to test causal models and they can be used for exploratory analysis, but statistical methods alone cannot determine the direction of causality. Moreover, any SEM depends on the assumption that you have included all relevant factors. The causal inference from SEMs is only as strong as the underlying theoretical support for the model and for the choice of causal factors. Temporal analysis can in some cases resolve direction of causality, but can never solve the problem of relevant factors.

I think that the PACE team should contemplate the meaning of scientific models, in particular the difference between causal models and black box correlational models.

 

How long can these people go on making idiots of themselves?

 

Probably their own special kind of stats, explaining how to understand causal relationships that don't exist.

 

You clearly enjoy fiction then.

 

Lifetime achievement?

 

For as long as they can get away with it

 

Suggested alternative title:

Tutorial: The Practical Guide How to Create a (Bio)psychosocial Pseudomodel for an Illness of Arbitrary Etiology