Trends in Molecular Medicine - Immune system perturbations in patients with long COVID, Rodrigues, Brodin, 2024

Abstract
Klein et al. report multimodal analyses of immune cells, proteins, and physiological parameters in patients with long COVID (LC). At the group level, LC subjects exhibited elevated antibody responses to SARS-CoV-2, but also to herpes viruses, pointing to a general suppression of viral control mechanisms in LC.

Main text

The aftermath of acute viral infections, occasionally marked by prolonged symptoms and sometimes chronic sequelae, has long perplexed the medical community. While the phenomenon is likely quite widespread, understanding its underlying pathogenesis in conditions like myalgic encephalomyelitis(ME)/chronic fatigue syndrome has proven difficult. The challenge has been to connect diverse sets of infections with prolonged and highly variable symptoms only recognized months to years later upon ME diagnosis. Treatmentinterventions can show some benefit, but the underlying pathologic mechanisms remain unknown [1]. The emergence of LC in the wake of the coronavirus disease 2019 (COVID-19) pandemic offers a unique opportunity to understand postinfectious disorders, as the novel virus caused prolonged symptoms which can be investigated

https://www.sciencedirect.com/science/article/pii/S1471491423003027

 

That would be a great outcome of a terrible time.

 

Commentary on Distinguishing features of Long COVID identified through immune profiling (2023, Nature)