Moderator note: This post and several following have been moved from this thread: 3rd Annual Community Symposium on the Molecular Basis of ME/CFS at Stanford University, sponsored by OMF, 7th Sept 2019 ________________________________________ Hillary Johnson @oslersweb 9h9 hours ago Ron Davis: SS-19, an experimental drug that repairs mitochondria, designed for people with congestive heart failure, turned ME blood into control blood. OMF working with inventor. http://novelconjugates.com/product/tyrosol-ss19carbamate/ Tyrosol-SS19(Carbamate) novelconjugates June 12, 2018 No Comments $800.00 Quantity: 25mg SKU: 3204004 Category: Peptide conjugates Tag: Tyrosol-Szeto-Schiller peptide Description Additional information Description Product Name: Tyrosol-SS19(Carbamate) Synonyms: Tyrosol-Tyr-D-Arg-Phe-Lys-NH2, Cat#: 3204004 M.F.: C39H53N9O8 M.W.: 775.91 Description: In addition to its antioxidative effects, tyrosol has the neuroprotective, anti-inflammatory, antiaging, and antifungal properties. SS19 is one of the small, cell-permeable antioxidant peptides (Szeto-Schiller or SS peptides) that are known to protect mitochondria from oxidative damage. http://novelconjugates.com/product/resveratrol-ss19carbamate/ Resveratrol-SS19(Carbamate) novelconjugates June 12, 2018 No Comments $800.00 Quantity: 25mg SKU: 3204003 Category: Peptide conjugates Tags: Resveratrol-SS19, Resveratrol-Szeto-Schiller peptide Description Additional information Description Product Name: Resveratrol-SS19(Carbamate) Synonyms: Resveratrol-Tyr-D-Arg-Phe-Lys-NH2, Cat#: 3204003 M.F.: C45H55N9O9 M.W.: 865.99 Description: Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a natural phytoalexin found in grape-skin, exerts multiple biological activities, including anti-inflammatory, antiproliferative and antioxidant effects. SS19 is one of the small, cell-permeable antioxidant peptides (Szeto-Schiller or SS peptides) that are known to protect mitochondria from oxidative damage. http://novelconjugates.com/product/ss31/ Szeto-Schiller peptide(SS31） novelconjugates June 12, 2018 No Comments $1,500.00 Quantity: 25mg SKU: 3902004 Category: Peptides Tags: SS31, Szeto-Schiller (SS) peptides Description Additional information Description Product name: SS31 Synonym: Elamipretide, Bendavia, H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2, H-D-Arg-Dmt-Lys-Phe-NH2, IUPAC Name: (2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide, Catalog #: 3902004 CAS No.: 736992-21-5 Molecular Formula: C32H49N9O5 Molecular Weight: 639.80 Description: SS31 is a tetra-peptide, cell-permeable, mitochondria-targeted molecule. The SS31 is one of the four molecules (SS31, SS02, SS19, SS20) developed by Szeto and Schiller that is capable of targeting and permeating to mitochondria. The chemical structure of SS31 is H-D-Arg-Dmt-Lys-Phe-NH2, and its structural motif centers on alternating aromatic residues and basic amino acids. SS31 has a sequence motif that allows it to target mitochondria, scavenge free radicals, including H2O2 and ONOO−, and inhibit lipid peroxidation. Its capability of protecting to be attributed to tyrosine, or dimethyltyrosine, a residue that scavenges oxyradicals and forms relatively unreactive tyrosyl radicals. The unreactive tyrosyl radicals trigger the coupling of tyrosyl radicals to each other, giving rise to dityrosine, which reacts with a superoxide to form tyrosine hydroperoxide. Recently, the efficacy of SS31 was studied in rodent models of ischemic brain injury, diabetes, myocardial infarction and amyotrophic lateral sclerosis (ALS). These researchers found that SS31 protects cells from mitochondrial toxicity in all of these disease states. SS-31 represents a novel platform of mitochondria-targeted antioxidants with broad therapeutic potential.