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TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity, 2020, Arlt et al

Discussion in 'Immune: Autoimmune and Mast Cell Disorders' started by Andy, Jul 27, 2020.

  1. Andy

    Andy Committee Member

    Hampshire, UK
    Open access, https://www.pnas.org/content/early/2020/07/10/1920122117

    Press release, https://www.en.uni-muenchen.de/news/newsarchiv/2020/zierler_ionenkanal.html
  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

    I've come to realise that all these papers that look at one protein and it's effect on one particular cell are interesting, but cells have a large number of receptors and many things can affect them. TPC1 will only be one of many. In addition TPC1 has other effects that may have major consequences on health not related to mast cells. This is from Gene Cards for the gene TPCN1 that encodes protein TPC1.
    Source : https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPCN1

    In addition there are many other calcium channels that could also play an effect.........

    Here is just the first hit on a search of "mast cells calcium". There are many many things that affect calcium signalling in mast cells.
    REGULATORS OF CA2+ SIGNALING IN MAST CELLS Potential Targets for Treatment of Mast-Cell Related Diseases?
    obeat and Andy like this.

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