A story on Australian radio Tuesday morning local time covered a paper in the journal Nature (the audio won't play outside Australia, so for those overseas I'll try to find the study link and post below). According to the researcher interviewed in the radio piece, too much salt changes the gut composition and creates "an almost auto-immune effect in the brain". I find this fascinating. I certainly retain more water & salt when I'm PEMmed. I'm just one big bloat! My ME doctor routinely orders a 24 hr sodium-potassium excretion test, and has found that many PWME retain too much salt. Professor Ron Davis is mimicking PEM by stressing the cells of PWME with salt, so he can see whether/how the stressed cells respond to every drug currently approved by the FDA.