Open [Tokyo, Japan] Study of the Efficacy and Safety for Rituximab in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

[Utsikt]

But what if it reports positive results?!

I think it's worth a philosophical discussion about how to manage that.

Wouldn’t that depend on what the actual results are and what kind of data we get access to?

 

[ryanc97]

So any updates on trial? Didn’t here much from them at the charite conf

 

[Murph]

Wouldn’t that depend on what the actual results are and what kind of data we get access to?

Precisely. What would it take to change minds?

If they reported a benefit of Ritux, then for me to find it credible I think I'd want to see some pretty strong effect sizes, evidence of a scrupulous study, and probably also some deep exploratory investigations that create a plausible narrative of why it worked for the patients it worked in. Even then you'd probably want to combine the data with Fluge and Mella for a meta analysis.

They face an uphill battle to show anything persuasive, but it's really important to not fall into primacy bias where you hold on tight to the first information you get. There's also home bias to overcome, where english speakers and Europeans might be more convinced by research from Europe...