Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship, 2022, Gorini et al

Title : Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship

Link : https://www.researchgate.net/profil...elenium-in-This-Intermingled-Relationship.pdf

Authors : Francesca Gorini 1, *, Laura Sabatino 1 , Alessio Coi 1, Giorgio Iervasi 1 and Cristina Vassalle 2,

1 Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy; laura.sabatino@ifc.cnr.it (L.S.);
alessio.coi@ifc.cnr.it (A.C.); iervasi@ifc.cnr.it (G.I.)
2 Fondazione CNR-Regione Toscana Gabriele Monasterio, 56124 Pisa, Italy
* Correspondence: fgorini@ifc.cnr.it (F.G.); cristina.vassalle@ftgm.it (C.V.

Abstract: [with paragraphs added]

COVID-19 represents a worldwide public health emergency, and, beyond the respiratory
symptoms characterizing the classic viral disease, growing evidence has highlighted a possible
reciprocal relationship between SARS-CoV-2 infection and thyroid dysfunction.

The updated data discussed in this review suggests a role of SARS-CoV-2 infection on the thyroid gland, with multiple thyroid pictures described. Conversely, no conclusion can be drawn on the association between pre-existing thyroid disease and increased risk of SARS-CoV-2 infection.

In this scenario, selenium (Se), an essential trace element critical for thyroid function and known as an effective agent against viral infections, is emerging as a potential novel therapeutic option for the treatment of COVID-19. Large multicentre cohort studies are required to elucidate the mechanisms underlying thyroid dysfunction during or following recovery from COVID-19, including Se status.

Meanwhile, clinical trials should be performed to evaluate whether adequate intake of Se can help address COVID-19 in Se-deficient patients, also avoiding thyroid complications that can contribute to worsening outcomes during infection.