Thesis: A neuroinflammatory paradigm can explain Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome and Post-COVID-19 Fatigue Syndrome

[FMMM1]

Interesting, and perhaps promising.

Although waiting another 10 years for a brain model of neuroinflammation is too long.

I hope these researchers are aware of Jarrad Younger's research on neuroimflammation
in ME.

Warren Tate was/is close to OMF and Jarrad Younger is also part of/associated with OMF --- so yes, I expect that Warren is aware of/if not directly in contact with Jarrad Younger re Jarrad's research

 

[FMMM1]

Reading the above I'm reminded of why we need a GWAS study --- GWAS may/should help to identify where research should be focused. From the above it's clear that ME/CFS could be due to many things --- (mis?) quoting Simon McGrath "I suspect it’s more productive to go from evidence [from GWAS] to hypothesis than from searching for evidence to back up an hypothesis. The latter has been tried for decades without much luck."
[https://www.s4me.info/threads/conve...-dyshomeostasis-2023-marks.31430/#post-455682]

Thanks to Jonathan, Simon and Chris --- we now have a GWAS study

 

[DokaGirl]

Warren Tate was/is close to OMF and Jarrad Younger is also part of/associated with OMF --- so yes, I expect that Warren is aware of/if not directly in contact with Jarrad Younger re Jarrad's research

Thanks.

 

[Dolphin]

I see that this author has written the following in the Australasian Medical Journal:
Mackay A. The Long-COVID Conundrum. AMJ 2023;16(11):787-789. https://doi.org/10.21767/AMJ.2023.3982

https://www.proquest.com/openview/e50a783e8050365b2fdc3e7cdf923517/1?pq-origsite=gscholar&cbl=54991

In addition, another major subgroup has become apparent; that of Long-COVID patients displaying Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) related symptoms [2] [3]. It is estimated that around half of individuals with Long-COVID meet the criteria for ME/CFS 2 . This would equate to around 5-10 million additional (LongCOVID related) ME/CFS patients in the USA, alone. However, no mention of any of these major subgroups (or possible subsets within) is provided by the WHO in their clinical case definition [1]. Consequently, contrasting definitions for Long-COVID have appeared in the literature. Some reviewers perceive it as pertaining only to the subgroup related to long-term ME/CFS-like symptoms3 , whereas others perceive Long-COVID as pertaining to all subgroups and long-term pathophysiological outcomes, some including those with ME/CFS-like symptoms and some without4 .