The symptom signaling theory of ME/CFS involving neurons and their synapses

[ChronicallyOverIt]

How does this hypothesis account for the waxing and waning of symptoms in severity level? As in people going from mild to severe, back to mild, repeat.

I remember some discussion of autoimmune diseases following a similar cycle, with periods of increased symptoms.

 

[jnmaciuch]

Busy today so don't have time to make a separate thread and analyze it, but this might be of interest:
An airway-to-brain sensory pathway mediates influenza-induced sickness

Came up in a journal club I was part of 2 years ago, unfortunately it was long enough ago that I don't remember my labmates' commentary. @Kitty you might be right on the mark with prostaglandins

[Edit: also this paper that I haven't had a chance to read in-depth yet:
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment]

 

[Mij]

I slept very well during onset ME and for the next 12 years. I had a disruption of initiating sleep for almost 2 years out of the blue. My sleep just switched off one night and came back almost 2 years later as though it was switched back on again. So weird.

My close friend had severe insomnia for 18 years that started from day one of illness.