Review The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID, 2024, Kane, Yonker et al.

The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID
Abigail S. Kane; Madeleine Godfrey; Magali Noval Rivas; Moshe Arditi; Alessio Fasano; Lael M. Yonker

The effects of SARS-CoV-2 infection on children continue to evolve following the onset of the COVID-19 pandemic. Although life-threatening multisystem inflammatory syndrome in children (MIS-C) has become rare, long-standing symptoms stemming from persistent immune activation beyond the resolution of acute SARS-CoV-2 infection contribute to major health sequelae and continue to pose an economic burden. Shared pathophysiologic mechanisms place MIS-C and long COVID within a vast spectrum of postinfectious conditions characterized by intestinal dysbiosis, increased gut permeability, and varying degrees of immune dysregulation.

Insights obtained from MIS-C will help shape our understanding of the more indolent and prevalent postacute sequelae of COVID and ultimately guide efforts to improve diagnosis and management of postinfectious complications of SARS-CoV-2 infection in children.

Link | PDF (Annual Review of Virology)