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The SMILES trial: do undisclosed recruitment practices explain the remarkably large effect? (2018) Molendijk et al.

Discussion in 'Health News and Research unrelated to ME/CFS' started by Cheshire, Dec 29, 2018.

  1. Cheshire

    Cheshire Moderator Staff Member

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    Open access here.

    Many similarities with the PACE flaws:

     
  2. Trish

    Trish Moderator Staff Member

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    So we now have a SMILE trial for LP in kids with ME, and a SMILES trial for diet changes for people with depression with a smiley face made out of fruit. I detect a correlation between infantile trial names and bad science.

    I wonder what would be the effect of calling a trial the FROWN trial, the GRIMACE trial, or perhaps even the EVIL trial. :devilish:
     
  3. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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    There recently was an IMAGINE trial in the Lancet Gastrology claiming that hypnotherapy decreases symptoms in irritable bowel syndrome (don't think it was discussed here). Unblinded with subjective outcomes of course. It also reminded me of the PACE-trial. See for example this quote:
     
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  4. Trish

    Trish Moderator Staff Member

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    No it bloody well isn't.
     
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  5. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Where does that snippet come from @Trish ? It is a real howler.
     
  6. Trish

    Trish Moderator Staff Member

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    Second sentence in the section Michiel quoted in the post before mine. From the IMAGINE trial. The whole paragraph he quoted is an expanded version of the same thing.
     
  7. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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    Yeah, how cynical that they chose to call their trial IMAGINE and make such statements in their main paper.
     
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  8. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    .....maybe the researchers are John Lennon fans?

    ' ......imagine all the people, living life in PACE' (?)
     
  9. rvallee

    rvallee Senior Member (Voting Rights)

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    I had to check and the study name specifically says it's for adults. They're trying to convince depressive adults that a smiley face banana will cure them, or something. And it seems like PACE set a sort of precedent with its newsletter with quotes promising a cure during the trial. That this was not severely punished made it acceptable moving forward. Very bad.

    Can't they do those studies without being extra condescending? I get it, some people require some extra coddling but this assumption that everyone who doesn't have a medical degree is a drooling idiot is a bit grating and very misguided.

    All I could think of:
     
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  10. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Best I could do on short notice:
    Exercise promoted Viley to cause Injury and Lethargy trial.
     
  11. Sean

    Sean Senior Member (Voting Rights)

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    From completely unfounded speculation to The Indisputable Truth, in one step.

    Nice work if you can get it. :rolleyes:
     
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  12. strategist

    strategist Senior Member (Voting Rights)

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    Statements like these make it clear that it's time for patients to take on a larger role in medicine and speak for themselves.
     

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