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The skinny on lipid immunology

Discussion in 'Other health news and research' started by Andy, Oct 25, 2017.

  1. Andy

    Andy Committee Member

    Hampshire, UK
    Phospholipids - fat molecules that form the membranes found around cells - make up almost half of the dry weight of cells, but when it comes to autoimmune diseases, their role has largely been overlooked. Recent research has pointed to a role for them in numerous diseases, including psoriasis, contact hypersensitivities and allergies. In a new study published in Science Immunology, researchers from Brigham and Women's Hospital and Monash University in Australia reveal new insights into the basis for T cell receptor (TCR) autoreactivity to self-phospholipids, with implications for autoimmune diseases.

    "Lipids have been under appreciated in immunology," said co-corresponding author D. Branch Moody, MD, a principal investigator in the Division of Rheumatology, Immunology and Allergy. "We've been interested in autoimmune diseases for decades, and it's thought that in certain autoimmune diseases like psoriasis, multiple sclerosis and type 1 diabetes are driven by particular tissues. The search for the particular molecules, known as antigens, that trigger autoimmune diseases has focused on proteins and peptides, but we should also be thinking about lipids as candidate antigens for autoimmune disease."
    Read more at https://www.eurekalert.org/pub_releases/2017-10/bawh-tso102017.php

    I believe this is the paper referred to;
    A molecular basis of human T cell receptor autoreactivity toward self-phospholipids, http://immunology.sciencemag.org/content/2/16/eaao1384
    Helen, Trish and Valentijn like this.

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