https://www.mdpi.com/2227-9059/10/11/2686
Abstract: CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward
substrates and are unique in that these enzymes metabolize both endogenous compounds and
diverse xenobiotics (including drugs); almost the only common characteristic of these compounds
is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in
human organs and tissues, and consequences of these enzymes’ activities play a major role both in
normal regulation of physiological levels of endogenous compounds and in various pathological
conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological
conditions and their involvement in the initiation and progression of diseases.
Abstract: CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward
substrates and are unique in that these enzymes metabolize both endogenous compounds and
diverse xenobiotics (including drugs); almost the only common characteristic of these compounds
is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in
human organs and tissues, and consequences of these enzymes’ activities play a major role both in
normal regulation of physiological levels of endogenous compounds and in various pathological
conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological
conditions and their involvement in the initiation and progression of diseases.