The promise of a model-based psychiatry: building computational models of mental ill health, 2022, Hauser et al

The promise of a model-based psychiatry: building computational models of mental ill health

Tobias U Hauser, Vasilisa Skvortsova, Munmun De Choudhury, Nikolaos Koutsouleris

Summary
Computational models have great potential to revolutionise psychiatry research and clinical practice. These models are now used across multiple subfields, including computational psychiatry and precision psychiatry. Their goals vary from understanding mechanisms underlying disorders to deriving reliable classification and personalised predictions. Rapid growth of new tools and data sources (eg, digital data, gamification, and social media) requires an understanding of the constraints and advantages of different modelling approaches in psychiatry. In this Series paper, we take a critical look at the range of computational models that are used in psychiatry and evaluate their advantages and disadvantages for different purposes and data sources. We describe mechanism-driven and mechanism-agnostic computational models and discuss how interpretability of models is crucial for clinical translation. Based on these evaluations, we provide recommendations on how to build computational models that are clinically useful.

This is the first in a Series of two papers about the digital mind: new concepts in mental health. All papers in the Series are available at www.thelancet.com/series/the-digital-mind

https://www.sciencedirect.com/science/article/pii/S2589750022001522