The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis

[Sly Saint]

Abstract
The sequalae of periodontitis include irreversible degradation of tooth-supporting structures and circulatory spread of inflammatory mediators. However, the serum protein profile in periodontitis is not well described, which is partly attributable to the limited number of studies based on large and well-characterized periodontitis cohorts. This study aims to identify novel, circulating inflammation-related proteins associated with periodontitis within the PerioGene North case-control study, which includes 478 cases with severe periodontitis and 509 periodontally healthy controls. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP) and a panel of 45 inflammation-related proteins were analyzed using targeted proteomics. A distinguishable serum protein profile was evident in periodontitis cases. The protein pattern could separate cases from controls with a sensitivity of 0.81 and specificity of 0.81 (area under the curve = 0.87). Adjusted levels for hs-CRP and 24 of the 45 proteins were different between cases and controls. High levels of hs-CRP and matrix metalloproteinase–12, and low levels of epidermal growth factor (EGF) and oxidized low-density lipoprotein receptor 1 (OLR-1) were detected among the cases. Furthermore, the levels of C-C motif chemokine–19, granulocyte colony-stimulating factor–3 (CSF-3), interleukin-7 (IL-7), and hs-CRP were significantly higher in cases with a high degree of gingival inflammation. The levels of CSF-3 and tumor necrosis factor ligand superfamily member–10 TNFSF-10 were higher in cases with many deep periodontal pockets. The PerioGene North study includes detailed clinical periodontal data and uncovers a distinct serum protein profile in periodontitis. The findings of lower EGF and OLR-1 among the cases are highlighted, as this has not been presented before. The role of EGF and OLR-1 in periodontitis pathogenesis and as possible future biomarkers should be further explored.

The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis - M. Wänman, S. Betnér, A. Esberg, C.K. Holm, C. Isehed, A. Holmlund, P. Palmqvist, A. Lövgren, S. Lindquist, L. Hänström, U.H. Lerner, E. Kindstedt, P. Lundberg, 2024 (sagepub.com)

 

[Sly Saint]

article explaining the research
Individuals with periodontitis exhibit unique inflammatory protein profile in the blood

Individuals with periodontitis have altered concentrations of various proteins in their blood, according to a new study from Umeå University, Sweden. These findings pave the way for research into biomarkers for periodontitis and the underlying causes of the disease. Severe periodontitis affects about one in ten Swedes and, in addition to tooth loss, can also be linked to other diseases.
"By identifying the blood biomarkers that may be crucial for the development of severe periodontitis, we can proceed to research drugs that specifically aims to slow down the disease progression," says Pernilla Lundberg, periodontist and professor at the Department of Odontology at Umeå University, who led the study.

Periodontitis involves inflammation of the gums that leads to the breakdown of the supporting tissues around the teeth and can, in severe cases, result in tooth loss. Individuals with severe periodontitis are also more often affected by other serious diseases, such as cardiovascular disease and rheumatism, but the mechanisms behind these connections remain unclear.

Researchers at Umeå University have now shown that individuals with periodontitis exhibit a unique inflammatory protein profile in their blood. The findings indicate, among other things, that severe periodontitis is associated with significantly reduced levels of a protein called EGF -epidermal growth factor, which is crucial for wound healing. The levels of a protein associated with cardiovascular disease, OLR-1 -oxidized low-density lipoprotein 1, are also significantly lower in individuals with severe periodontitis compared to healthy individuals.

Individuals with periodontitis exhibit unique inflammatory protein profile in the blood (msn.com)

 

[Mij]

This is an issue for pwRA.

 

[Sly Saint]

This is an issue for pwRA.

and many others
"Overall, 42.2% (standard error, ± 1.4) of adults 30 years or older in the United States had total periodontitis, consisting of 7.8% with severe periodontitis and 34.4% with nonsevere periodontitis."
Periodontal Disease in Adults (Age 30 or Older) | National Institute of Dental and Craniofacial Research (nih.gov)
eta:
a more recent article that I can't find has it at around 49% in the US.
figures are estimated around the same in UK.