1. Guest, the 'News in Brief' for the week beginning 22nd November 2021 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

The pathway from glandular fever to chronic fatigue syndrome, 2011, Moss-Morris et al

Discussion in 'PsychoSocial ME/CFS Research' started by Michiel Tack, May 6, 2019.

  1. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

    Copied from the New Zealand thread
    This is the paper she is referring to: The pathway from glandular fever to chronic fatigue syndrome: can the cognitive behavioural model provide the map?

    I think the paper is worth a discussion because it is one of the few papers that actually tried to test the CBT-model using a prospective design. My first impression is that they didn't correct for multiple comparisons, so many of the 'significant' results in the individual logistic regression analysis such as perfectionism should probably not have been reported as such.

    When all these factors were tested in a Multivariate logistic regression analysis along with gender, age and symptoms, only 'all-or-nothing behavior' remained a significant predictor. With correction for multiple comparisons, this would also be questioned. So I don't think these results are robust. The sample was also a bit small with only 17 EBV-patients who developed CFS after 6 months.
    Last edited by a moderator: May 7, 2019
  2. Hutan

    Hutan Moderator Staff Member

    New Zealand


    Background. The cognitive behavioural model of chronic fatigue syndrome (CFS) suggests that the illness is caused through reciprocal interactions between physiology, cognition, emotion and behaviour. The purpose of this study was to investigate whether the psychological factors operationalized in this model could predict the onset of CFS following an acute episode of infectious mononucleosis commonly known as glandular fever (GF).

    Method. A total of 246 patients with GF were recruited into this prospective cohort study. Standardized self-report measures of perceived stress, perfectionism, somatization, mood, illness beliefs and behaviour were completed at the time of their acute illness. Follow-up questionnaires determined the incidence of new-onset chronic fatigue (CF) at 3 months and CFS at 6 months post-infection.

    Results. Of the participants, 9.4% met the criteria for CF at 3 months and 7.8% met the criteria for CFS at 6 months. Logistic regression revealed that factors proposed to predispose people to CFS including anxiety, depression, somatization and perfectionism were associated with new-onset CFS. Negative illness beliefs including perceiving GF to be a serious, distressing condition, that will last a long time and is uncontrollable, and responding to symptoms in an all-or-nothing behavioural pattern were also significant predictors. All-or-nothing behaviour was the most significant predictor of CFS at 6 months. Perceived stress and consistently limiting activity at the time of GF were not significantly associated with CFS.

    Conclusions. The findings from this study provide support for the cognitive behavioural model and a good basis for developing prevention and early intervention strategies for CFS.
  3. Amw66

    Amw66 Senior Member (Voting Rights)

    Oxford/ Fukada for CFS?
    MEMarge, Invisible Woman and Ravn like this.
  4. rvallee

    rvallee Senior Member (Voting Rights)

  5. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    The predictors that were "significant" at 3 months disappeared at 6 months, suggesting they are not relevant.

    "all or nothing" behavioural questionnaire answers could be interesting, but could also represent biases in participation, those who felt their illness was significant enough to participate initially might have be blaming their stronger than expected symptoms on this behaviour for example.
  6. Ravn

    Ravn Senior Member (Voting Rights)

    'fraid so...
    I strongly suspect that whether or not you engage in "all or nothing behaviour" is as likely caused by your external circumstances at the time as by any fixed "personality" trait. I also strongly suspect the questionnaires used to identify such behaviour didn't distinguish between those different types of possible causes.
  7. Amw66

    Amw66 Senior Member (Voting Rights)

    Boom or bust by another name
  8. NelliePledge

    NelliePledge Moderator Staff Member

    UK West Midlands
    How do you know it’s having a revival @Sly Saint is it being mentioned in Facebook groups or getting online reviews or something?
  9. Dolphin

    Dolphin Senior Member (Voting Rights)


Share This Page