The LIFT trial (OMF) - Pyridostigmine (mestinon) and Low Dose Naltrexone (LDN)

Discussion in 'ME/CFS research news' started by LesPig, Nov 1, 2023.

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  1. cassava7

    cassava7 Senior Member (Voting Rights)

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    Does anyone have news of the Covid-19 to ME/CFS conversion study that was supposedly launched in 2020?

    Also, has the LDN/Mestinon trial been registered?
     
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  2. Perrier

    Perrier Senior Member (Voting Rights)

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    OMF just posted an interview with Dr. Systrom. Very discouraged here: gives the impression that Mestinon & LDN will help, and then doctors everywhere will be able to prescribe this off label. IN the USA many pts have tried the two already, years ago. CFS doctors were offering it to try. Pts did try. Sometimes there was a little bump upward, but it never lasted.
     
  3. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    Merged thread

    "Today Dr. Jonas Bergquist sits down to chat about OMF's first clinical trial, The Life Improvement Trial (LIFT). This clinical treatment trial is a major step towards understanding and treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID more effectively. What is The LIFT? Conducted under the direction of David Systrom, MD, Director of our Harvard Collaboration and Jonas Bergquist, MD, PhD, OMF’s Chief Medical Officer and Director of the Uppsala University Collaboration, The LIFT is a randomized, double-blind placebo trial that will investigate two particular drugs: Pyridostigmine (commonly known as Mestinon) and low-dose naltrexone (LDN) separately and together as a combination. Dr. Bergquist speaks more on trial setup, expected timelines of the trial, why this is an important first step, and more."

    transcript available at link

     
    Last edited by a moderator: Dec 1, 2023
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  4. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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  5. RedFox

    RedFox Senior Member (Voting Rights)

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  6. Kitty

    Kitty Senior Member (Voting Rights)

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    Yes, I've developed a tic that's triggered by acronyms, thanks to British psychosomatic research.
     
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  7. Starlight

    Starlight Senior Member (Voting Rights)

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    I might be completely wrong side out today but the acronym and trial title annoy me no end. Very crass for people who are bedbound housebound and severely disabled for decades. Sounds so happy clappy. I spent a year on ldn to no avail.
     
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  8. Dolphin

    Dolphin Senior Member (Voting Rights)

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  9. Marky

    Marky Senior Member (Voting Rights)

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    PACE yourself, LIFT is coming.
     
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  10. mango

    mango Senior Member (Voting Rights)

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    Peter Trewhitt and Trish like this.

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