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The gut microbiota mediates the anti-seizure effects of the ketogenic diet, 2018, Olson et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Indigophoton, May 24, 2018.

  1. Indigophoton

    Indigophoton Senior Member (Voting Rights)

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    I'm posting this because I've noticed some people mention finding a keto diet helpful for their ME.

    It seems that the keto diet potentially - tbc in humans - results in a couple of key types of gut bacteria that are found to modulate levels of GABA in the brain. GABA is increased relative to the excitory neurotransmitter glutamate, thus calming brain activity.

    So I wonder if those for whom keto is helpful are benefiting from the increased GABA (as, anecdotally at least, drugs and supplements that boost GABA are helpful to some pwme).

    The study was in mice, so the results may not prove to apply to humans, but interesting so far. It seems like a nice set of experiments.
    The article, https://m.medicalxpress.com/news/2018-05-gut-bacteria-key-role-anti-seizure.html
    The paper, https://www.cell.com/action/showImagesData?pii=S0092-8674(18)30520-8

    Full paper here, http://sci-hub.tw/10.1016/j.cell.2018.04.027
     
    Hutan, leokitten, andypants and 4 others like this.

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