Utsikt
Senior Member (Voting Rights)
That might be true here. But my experience is that not insignificant amount of people very much hold onto their pet treatments in LC groups.
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Trial Report Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid HOT-LoCO…, 2025, Kjellberg et al.
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rvallee
Senior Member (Voting Rights)
Oh, yes, subsets are common. There is also the occasional "brain retraining" post on the LC sub-reddit. Comments vary, there usually are a few who really vouch for it. Sometimes the posts get deleted because most of the early responses aren't positive. It varies. There are also still the occasional posts on supplement stacks. Some for exercise. Here and there. But like with HBOT, whereas there was a moment where it was talked about a lot, being a main topic of discussion, it all fell out of fashion and most people just ignore it now.
Great to see a good quality trial, even if it has a null result.
Karolinska University, Sweden.
Adequately sized trial
I guess it is always possible to say 'ah, but the treatment should have been slightly different' - given for longer, given at a higher dose, given by better trained therapists... But still, this is useful.
Karolinska University, Sweden.
Adequately sized trial
I guess it is always possible to say 'ah, but the treatment should have been slightly different' - given for longer, given at a higher dose, given by better trained therapists... But still, this is useful.
That's an interesting organisation - International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human use-Good Clinical Practice - website here: https://www.ich.org/
Great to see this. I'm assuming this is a good association?
The following is a lot, but it looks as though they have really tried hard to reduce bias and do things well. They also paid a lot of attention to blinding.
Inclusion criteria are basically healthy and working/studying prior to Covid-19 infection, persisting symptoms post-Covid-19 infection for at least 12 weeks and ongoing, diagnosed with a post-covid-19 condition. The people included were mostly fairly young, healthy BMI.
Change in SF-36 Physical Function
(note, SF-36 Physical Function is the 10 questions about things like whether you can walk a block or a mile, or climb a flight of stairs or 3, or have trouble bathing and dressing. RP is Role Physical - 4 questions asking things like 'were you limited in the work or activities you could do due to your physical health?'.
I wanted to highlight this. Higher scores mean better physical health. These people were scoring in the 0 to 50 range, which is low compared to the general population, but, I think, in line with what people with an ME/CFS-type illness participating in a trial would report.
The mean improvement was an increase of around 9 on the 0-100 scale from a baseline score of about 38. That's a pretty substantial improvement in percentage terms, nearly 25%. And that is from both a convincing placebo and from a treatment that turned out to be no better than a placebo that I expect most of the participants would have been very hopeful about. The treatment did not involve instruction in the benefits of ignoring symptoms, thinking positively or reframing symptoms as benign, nor did it specifically encourage people to increase their physical activity.
(note, SF-36 Physical Function is the 10 questions about things like whether you can walk a block or a mile, or climb a flight of stairs or 3, or have trouble bathing and dressing. RP is Role Physical - 4 questions asking things like 'were you limited in the work or activities you could do due to your physical health?'.
I wanted to highlight this. Higher scores mean better physical health. These people were scoring in the 0 to 50 range, which is low compared to the general population, but, I think, in line with what people with an ME/CFS-type illness participating in a trial would report.
The mean improvement was an increase of around 9 on the 0-100 scale from a baseline score of about 38. That's a pretty substantial improvement in percentage terms, nearly 25%. And that is from both a convincing placebo and from a treatment that turned out to be no better than a placebo that I expect most of the participants would have been very hopeful about. The treatment did not involve instruction in the benefits of ignoring symptoms, thinking positively or reframing symptoms as benign, nor did it specifically encourage people to increase their physical activity.
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Utsikt
Senior Member (Voting Rights)
I have not followed them closely, but the general impression in Norways is positive. They got up and running very soon into the pandemic and I believe they have been able to employ someone. They collaborate with their Scandinavian counterparts as well.