Teclistamab-Induced Remission in Refractory Systemic Lupus Erythematosus

OrganicChilli

OrganicChilli

Senior Member (Voting Rights)
Abstract

A woman with aggressive refractory systemic lupus erythematosus was treated with a short course of the bispecific antibody teclistamab (anti–B-cell maturation antigen and anti-CD3) and had a drug-free complete remission.

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Full article if you follow the link in the comments (not sure if it's allowed to post on S4ME):

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OrganicChilli said:
Yes, but I don't have an account and therefore no access.
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Aah, just noticed that I have access in Norway because of a national licence.
Treatment with teclistamab led to a rapid depletion of peripheral-blood B cells (by week 1), as well as a vast eradication of bone marrow plasma cells and B cells (by week 8).
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This case shows that short-term treatment with a bispecific BCMA-directed antibody induced a rapid and drug-free complete remission of SLE by depleting long-lived plasma cells and memory B cells. The response in our patient was remarkable and could position bispecific BCMA-directed antibodies as a future off-the-shelf treatment, potentially with incidences of response similar to those obtained with anti-CD19 CAR T-cell therapies. However, a longer follow-up period, particularly until the occurrence of B-cell repopulation, and treatment of a larger patient population are needed to determine the incidence and duration of response.
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Anything in specific you’re looking for?
 
We are looking for drugs that kill pesky LLPCs. Dara is one but is dependent on NK cells. Teclistamab uses T cells.
 
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