Teclistamab-Induced Remission in Refractory Systemic Lupus Erythematosus

[OrganicChilli]

Abstract

A woman with aggressive refractory systemic lupus erythematosus was treated with a short course of the bispecific antibody teclistamab (anti–B-cell maturation antigen and anti-CD3) and had a drug-free complete remission.

Link

Full article if you follow the link in the comments (not sure if it's allowed to post on S4ME):

Reddit

 

[Utsikt]

Is it this one?

https://www.nejm.org/doi/full/10.1056/NEJMc2407150

 

[OrganicChilli]

Is it this one?

https://www.nejm.org/doi/full/10.1056/NEJMc2407150

Yes, but I don't have an account and therefore no access. But the reddit comment with the link to the PDF is legit.

 

[Utsikt]

Yes, but I don't have an account and therefore no access.

Aah, just noticed that I have access in Norway because of a national licence.

Treatment with teclistamab led to a rapid depletion of peripheral-blood B cells (by week 1), as well as a vast eradication of bone marrow plasma cells and B cells (by week 8).

This case shows that short-term treatment with a bispecific BCMA-directed antibody induced a rapid and drug-free complete remission of SLE by depleting long-lived plasma cells and memory B cells. The response in our patient was remarkable and could position bispecific BCMA-directed antibodies as a future off-the-shelf treatment, potentially with incidences of response similar to those obtained with anti-CD19 CAR T-cell therapies. However, a longer follow-up period, particularly until the occurrence of B-cell repopulation, and treatment of a larger patient population are needed to determine the incidence and duration of response.

Anything in specific you’re looking for?

 

[OrganicChilli]

Anything in specific you’re looking for?

I mostly posted this for documentation because we had a thread on teclistamab the other day.

 

[ryanc97]

We are looking for drugs that kill pesky LLPCs. Dara is one but is dependent on NK cells. Teclistamab uses T cells.