A few Points,
0) is there evidence that he wants to enrich himself? He has an onkological clinic, He could Just do His everyday Work and be fine.
I think what he does is a good way to get a sued and lose money or worse.
Also from His Twitter it seems Like He tries to prescribes things via insurance and then hassels with the insurance company.
He Just seems Like a crazy, overconfident guy, who is willing to take risks, and does not Care about spelling. And I mean this positive. I think the enrichment is more emotional and Not monitary.
i)Teclistamab has evidence to Work for (other?) autoimundiseases.
E.g.
Information on the range of services at Charité – Universtätsmedizin Berlin for patients, physicians, students and scientists
sonntagsvorlesung.charite.de
We report the case of a 76‐year‐old woman with refractory immune thrombocytopenia (ITP) and multiple myeloma (MM) who achieved remission of both conditions following teclistamab treatment. After failing multiple ITP therapies, her platelet count ...
pmc.ncbi.nlm.nih.gov
It is further similar to Dara as in that It also Targets LLPC.
And is usually given in cancer patients after a CD38 mab has been tried.
So there is some reasoning behind it, and its Not some crazy baseles Experiment.
ii) concerning consent: As I mentioned before, different people have different "Personal cost functions". Data for Tecil risk is available, and currently It seems that people go to Habets especially because they want these kind of treatments, and we can not just assume that their consent is "not real".
People do all kind of dangerous things to have mundane and fleeting benefits: to get some short Adrenalin kick, to have some fun, to impress someone etc.;
it is plausible that there are people willing to take a risk to get even a small chance to get rid of something that literally sucks life dry for years and years.
iii) concerning the data:
Above all, I do not think that he gives Tecil to people with the goal to collect data, this would be (inspired but) unethical.
You should only give Treatment to a Patient If you think that the expected outcome for that Patient will be positive.
Collecting Data is an add on.
The Claim that the Data is unusable and the Arguments given for that Claim are unconvincing for me.
The cyclo trial begun by annecdotal evidence. Some people did Chemo, felt better, and reportet: I feel better.
This is def Not great Data - but It was enough to indicate further investigation.
Of course you can argue here that there was less reason for Placebo in the Cyclo case because people were Not expecting to get better, but there are other ways in which this Data is "muddy".
I think we Just really need to have a good Prior with which we Interpret this Data -- because we simply are not in a position to do science from the Ivory Tower.