Taking Biotin supplement? A very important warning...

Discussion in 'Other health news and research' started by TrixieStix, Nov 29, 2017.

  1. TrixieStix

    TrixieStix Senior Member (Voting Rights)

    Biotin Supplements Can Interfere With Cardiac Troponin Tests:

    One person died after excessive levels of biotin, also known as vitamin B7, skewed their troponin test results, according to the FDA.

    The US Food and Drug Administration (FDA) is warning physicians and other healthcare professionals that megadoses of supplementary biotin can result in skewed laboratory test results, including incorrect cardiac troponin measurements.


  2. Daisybell

    Daisybell Senior Member (Voting Rights)

    New Zealand
    The article also says that taking biotin might affect your TSH test results - something to be aware of for those of us having regular blood tests for thyroid function....
  3. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

  4. MeSci

    MeSci Senior Member (Voting Rights)

    Cornwall, UK
    There is an article in Physician's Health Watch about it now:

    Biotin (Vitamin B7) Supplementation Could Affect Lab Results
    By Kelly Young
    Edited by
    - David G. Fairchild, MD, MPH, and
    - Lorenzo Di Francesco, MD, FACP, FHM

    The FDA is reporting an increase in adverse events and one death tied to inaccurate lab results due to interference of the supplement biotin (vitamin B7).

    In addition to its role as a dietary supplement, biotin is used in lab tests because it binds to certain proteins. Accordingly, ingestion of high levels of biotin can lead to falsely high or low lab test results. The reported fatality occurred in a patient taking high levels of biotin who had a falsely low troponin test.

    Clinicians may be recommending high-dose biotin for patients with multiple sclerosis. Biotin is also found in multivitamins and prenatal vitamins. In addition, dietary supplements touting biotin's benefits for hair, skin, and nail growth may contain up to 650 times the recommended daily intake (0.03 mg).

    Clinicians should ask whether patients are taking biotin supplements, and this information should be conveyed to the laboratory. If test results do not match a patient's clinical presentation, providers should consider whether biotin may be interfering.

    FDA MedWatch safety alert (Free) http://response.jwatch.org/t?ctl=25E8E:5FF9B588B7CB016C79269638EFA1DB69&
    Background: NEJM Journal Watch Neurology coverage of biotin for multiple sclerosis (Your NEJM Journal Watch registration required) http://response.jwatch.org/t?ctl=25E8F:5FF9B588B7CB016C79269638EFA1DB69&
    Background: Physician's First Watch coverage of children's supplements containing high levels of biotin and other vitamins (Free) http://response.jwatch.org/t?ctl=25E90:5FF9B588B7CB016C79269638EFA1DB69&
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  5. Inara

    Inara Senior Member (Voting Rights)

    What I don't understand with regard to the death case - apart from the lab result, weren't there some symptoms?
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  6. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

    I was reading between the lines on the death case too - the amount of info was a bit limited. I just assumed the person was suffering from symptoms of a heart attack, ended up in hospital, had a troponin test which came back negative and so the full list of heart attack checks wasn't carried out and he either died in hospital or was discharged early and died later from the untreated heart attack.

    But then it makes you wonder if doctors think the troponin test is infallible and ignore the patient's symptoms if they don't match the test result. I'm sure doctors would believe blood tests over a patient any day of the week, to be honest, even in cases where symptoms were very serious.
  7. Inara

    Inara Senior Member (Voting Rights)

    That was what I was thinking. Heart stroke symptoms are clear, most often, especially in men. Maybe they thought he had a psychological issue after the normal troponin test.

    In case of TSH, ft3 anf ft4 results it might be much more difficult with clinical symptoms, but in the article above the values were very high, suggesting strong hyperthyroidsm which should show clinical symptoms. Somehow strange...at least here more tests were performed.

    Very interesting, that topic!
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  8. alicec

    alicec Senior Member (Voting Rights)

    Brisbane, Australia
    Whether or not biotin interferes with pathology tests entirely depends upon the use of the biotin-streptavidin capture system in immunoassays.

    Immunoassays don't necessarily use this system.

    You can only know if biotin is likely to be a problem by asking the path lab specifically which if any of their assays use biotin-streptavidin.
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  9. Dolphin

    Dolphin Senior Member (Voting Rights)


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