Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine, 2020, Cortez et al

Andy · Nov 21, 2020

Purpose
Up to 90% of patients with postural tachycardia syndrome (PoTS) report headaches, and comorbid migraine headaches are common. Given this, pathophysiological interaction is possible, which may reveal key aspects of disease expression and treatment opportunities. We hypothesized that PoTS subjects—both with and without migraine—would show features of central sensitization, including allodynia and photophobia.

Methods
Eighty participants were evaluated, including 30 PoTS, 30 chronic migraine (CM), and 20 non-headache healthy controls (NH), using tilt table testing, psychophysical assessment of sensory sensitivity thresholds, and an online questionnaire to assess measures of headache burden and associated symptoms. Clinical characteristics and sensory thresholds were compared between disease groups and controls, as well as in a subgroup analysis within the PoTS group, based on headache phenotype.

Results
Sensory sensitivity thresholds were significantly lower and symptom scores were higher in both the PoTS and CM groups compared to controls. However, the patterns of expression differed between PoTS and CM, with pain threshold reductions in the forearm only of PoTS subjects (non-trigeminal sensory sensitization), compared to both periorbital and forearm sites in CM. Unexpectedly, light sensitivity thresholds were significantly lower in PoTS than in both CM and NH.

Conclusions
These findings reveal an underappreciated aspect of disease burden in PoTS, and suggest network sensitization similar to, but separable from, that of migraine. The presence of both photophobia and allodynia in PoTS is reflective of exteroceptive rather than strictly interoceptive disruption, and expands our fundamental understanding of the disorder.
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Paywall, https://link.springer.com/article/10.1007/s10286-020-00740-y
Sci hub, https://sci-hub.se/10.1007/s10286-020-00740-y

alktipping · Nov 21, 2020

i thought everyone with a headache was more sensitive to light . i still have not seen any real evidence of this central sensitisation theory we do not in my opinion have the right equipment or expertise to to definitively state anything about what is going on in the brain other than best guesses which is not exceptable to me as evidence.

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Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine, 2020, Cortez et al

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Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine, 2020, Cortez et al

Andy Committee Member & Outreach

alktipping Senior Member (Voting Rights)

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