Study shows yogurt may dampen chronic inflammation linked to multiple diseases

Indigophoton · May 14, 2018

Inflammation can be good. It's part of the body's innate immune system, our first line of defense against illness and injury.

However, if the inflammatory response goes on for too long, it can lead to a condition called chronic inflammation, where the body essentially attacks itself, wreaking biological havoc on our organs and systems. Chronic inflammation is a factor in inflammatory bowel disease, arthritis and asthma. It is also associated with obesity, metabolic syndrome, cardiovascular disease, and other chronic diseases.

A recent study—described in two papers, including one published today (May 14) in the Journal of Nutrition—provides new evidence that yogurt may help dampen chronic inflammation. The study explored the hypothesis that yogurt may help reduce inflammation by improving the integrity of the intestinal lining, thus preventing endotoxins—pro-inflammatory molecules produced by gut microbes—from crossing into the blood stream.
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The article, https://medicalxpress.com/news/2018-05-yogurt-dampen-chronic-inflammation-linked.amp

From the Journal of Nutrition paper,

Premeal Low-Fat Yogurt Consumption Reduces Postprandial Inflammation and Markers of Endotoxin Exposure in Healthy Premenopausal Women in a Randomized Controlled Trial
https://doi.org/10.1093/jn/nxy046
Abstract
Background
Metabolic endotoxemia is associated with obesity and contributes to postprandial inflammation.

Objective
We aimed to determine if low-fat yogurt consumption prevents postprandial inflammation and dysmetabolism in healthy women by inhibiting biomarkers of metabolic endotoxemia.

Methods
Premenopausal women defined as obese and nonobese [body mass index (BMI, in kg/m2) 30–40 and 18.5–27, respectively, n = 120] were randomly assigned to consume 339 g of low-fat yogurt (YN, yogurt nonobese; YO, yogurt obese) or 324 g of soy pudding (CN, control nonobese; CO, control obese) for 9 wk (n = 30/group). The intervention foods each supplied 330 kcal with 3 g fat, 66 g carbohydrate, and 4–6 g protein. At weeks 0 and 9, participants ingested 226 g of yogurt or 216 g of soy pudding before a meal providing 56–60 g fat, 82 g carbohydrate, and 28–30 g protein. Plasma soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP), LPS activity, interleukin-6 (IL-6), glucose, triglyceride, and insulin were measured hourly for 4 h to assess differences in postprandial responses between groups by 2-factor ANOVA.

Results
Premeal yogurt consumption prevented the postprandial decrease in sCD14 net incremental area under the curve (net iAUC) by 72% in obese individuals at week 0 (P = 0.0323). YN and YO had ≥40% lower net iAUC of LBP-to-sCD14 ratio and plasma IL-6 concentration than CN and CO, respectively (P < 0.05). CO had postprandial hyperglycemia which was not evident in YO; in contrast YN had 57% less postprandial hypoglycemia than did CN (P-interaction = 0.0013). After 9 wk of yogurt consumption, ΔAUC of LBP-to-sCD14 ratios of YO and YN were less than half of those of the control groups (P = 0.0093).

Conclusions
Yogurt consumption improved postprandial metabolism and biomarkers of metabolic endotoxemia in healthy premenopausal women. Premeal yogurt consumption is a feasible strategy to inhibit postprandial dysmetabolism and thus may reduce cardiometabolic risk. This trial was registered at clinicaltrials.gov as NCT01686204.
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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy046/4995046

Andy · May 14, 2018

Bolling's study doesn't identify which compounds in yogurt are responsible for the shift in biomarkers associated with the health-promoting effect—or how they act in the body.
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My bet is that it is changing the gut microbiome.

Dolphin · May 14, 2018

This adds to one's calories. One would need to cut down other calories to compensate. Moving towards smaller meals has helped me lose weight.

Binkie4 · May 14, 2018

Well having just eaten a coyo yogurt, I am glad I am eating to reduce inflammation.
It says low fat yogurt but I believed low fat food often has increased sugar to make it palatable. How does that fit with reducing inflammation?

http://www.fatboysdiet.com/warning-muller-lights-worse-than-we-first-thought

Samuel · May 14, 2018

"funded by the National Dairy Council, a non-profit organization supported by the U.S. Department of Agriculture's national dairy checkoff program" -- article

"Since 1915, National Dairy Council (NDC) has been a non-profit organization founded by dairy farmers and funded through the national dairy checkoff program." -- https://www.nationaldairycouncil.org/our-story

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Study shows yogurt may dampen chronic inflammation linked to multiple diseases

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